CAS: 65473-14-5; (E)-N-Methyl-N-(Naphthalen-1-Ylmethyl)-3-Phenylprop-2-En-1-Amine Hydrochloride

3-苯基丙-2-烯-1-醇置于氯化亚砜,Sodium Hydroxide体系中,用 乙醇,二氯甲烷,甲苯 作为反应溶剂,化学反应 14.5H,反应生成 盐酸萘替芬
参考文献:一种盐酸萘替芬的制备方法
标题:一种盐酸萘替芬的制备方法
摘要:本发明提供一种盐酸萘替芬的制备方法,以相对廉价的肉桂醇为原料,依次经氯代试剂氯代,甲胺化,1‑氯甲基萘取代,最后酸化成盐,结晶精制,得到成品.本发明的制备方法中前三步反应中的各中间体均无需纯化便进行反应,工艺过程持续无间歇,简化了操作,提高了产品的收率和生产效率,同时确保了产品的纯度,适合产业化,同时具有反应条件简单,成本低,环境友好的优点.

专利信息

专利号:US-2025228841-A1
优先权日:2024-01-12
标题 :Compositions affecting pigment production and methods for treatment of bacterial diseases
发明人：Lee Wai Yip Thomas; LO KAI YIP GEORGE
权利人:APTORUM THERAPEUTICS LTD
摘要:Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II):The present methods include administering to a subject an effective amount of one or more compounds of Formula (II). In one embodiment, said microbial infections are bacterial infections. More specifically, the bacterial infections are staphylococcal infections. Compositions are provided that include compounds of formula II in combination with one or more antibiotics or one or more staphyloxanthin-synthesis-inhibiting compounds.

专利号:RU-2187488-C2
优先权日:1996-01-05
标 题:Method of synthesis of 1,1-difluoroethane

专利号:US-6403576-B1
优先权日:1998-08-24
标题 :Antifungal and antiparasitic compounds
发明人：JACKSON JOAN E; IWU MAURICE M; OKUNJI CHRISTOPHER O; BACCHI CYRUS; TALLY JR JOHN D; AYAFOR JOHNSON F
权利人:US ARMY
摘要:Novel antiparasitic and antifungal compositions are disclosed. The antiparasitic and antifungal compositions are useful for human and veterinary therapy for the treatment and/or prevention of parasitic infection. Also disclosed are novel mechanisms of identifying antifungal and antiparasitic compositions by their biochemical action on lipid synthesis and/or metabolism and/or excretion.

专利号:US-10829464-B2
优先权日:2016-11-23
标题 :Benzoheterocyclic alkylamine compounds and use thereof
发明人：LI JIAN; LAN LEFU; LI BAOLI; CHEN FEIFEI; NI SHUAISHUAI; LIU YIFU; WEI HANWEN; MAO FEI; ZHU JIN
权利人:UNIV EAST CHINA SCIENCE & TECH; SHANGHAI INST MATERIA MEDICA CAS
摘要:Disclosed are benzoheterocyclic alkylamine compounds, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, and a preparation method thereof, and use of the same in the manufacture of an antibacterial drug as an inhibitor of staphyloxanthin synthesis in Staphylococcus aureus .

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.