Cholesterol置于二乙酰基胺,对甲苯磺酸,甲苯体系中,化学反应生成 胆固醇醋酸酯 参考文献:Kocor Et Al.,Bulletin De L'Academie Polonaise Des Sciences,Serie Des Sciences Chimiques,1958,Vol. 6,P. 1,2 标题:Kocor Et Al.,Bulletin De L'Academie Polonaise Des Sciences,Serie Des Sciences Chimiques,1958,Vol. 6,P. 1,2
专利号:WO-9419366-A1 优先权日:1993-02-26 标题 :Chemical synthesis of squalamine 发明人:MORIARTY ROBERT M; GUO LIANG; TULADHAR SUDERSAN M 权利人:MAGAININ PHARMA 摘要:Methods for the chemical preparation or synthesis of the sterol antibiotic squalamine. Preferably, the preparation is by modifying the 3-position of a 3-oxo-7α-hydroxy-24z-ether protected alcohol group-5α-cholestane with a spermidino moiety to form a 3β-spermidino-7α-hydroxy-24z-ether protected group -5α-cholestane; deprotecting the 24-position of the 3β-spermidino-7α-hydroxy-24z-ether protected group-5α-cholestane to the free hydroxyl; and sulfating the 24-position of the 3β-spermidino-7α, 24-dihydroxy-5α-cholestane.
专利号:US-5338686-A 优先权日:1992-04-29 标 题:Method for measuring in vivo synthesis of biopolymers 发明人:HELLERSTEIN MARC K 权利人:HELLERSTEIN MARC K 摘要:A method for determining the mass isotope enrichment of a subunit from which a biopolymer is formed, and the rates of synthesis and decay of the biopolymer. The mass isotope enrichment of the subunit is determined by comparing the mass isotopomer distribution of the biopolymer after administration of a mass isotopically labeled subunit, with the expected frequencies of the different mass isotopomers produced from a given subunit mass isotope enrichment. To determine the synthesis rate of the biopolymer, the expected frequency of a selected biopolymer mass isotopomer, calculated from the subunit isotope enrichment, is compared with the actual frequency of that biopolymer mass isotopomer. To determine biopolymer decay, the decay rate of high mass isotopomers of the biopolymer is determined.
专利号:WO-2021005618-A1 优先权日:2019-07-09 标题:Synthesis of cholesterol and vitamin d3 from phytosterols
专利号:CA-2640585-A1 优先权日:2003-02-05 标题 :Synthesis of 2-butyl-3-(2'-(1-trityl-1h-tetrazol-5-yl)biphenyl-4-yl)-1,3-diazaspirol{4,4}-non-ene-4-one
专利号:US-8853194-B2 优先权日:2009-07-28 标 题:Sterol derivatives and their synthesis and use 发明人:CHEN DAGANG; LEI HAIMIN 权利人:CHEN DAGANG; LEI HAIMIN 摘要:Sterol derivatives with structural formula I or II are disclosed, wherein R is defined as the description of the invention. Their synthesizing methods and anti-tumor use are also disclosed. Especially, the compound of formula I, in which R is O (i.e. the compound CL 168-6), has the anti-tumor therapeutic index of 49.3. The compound can be used to prepare a medicine for prevention or treatment of immunological diseases and cancers such as liver cancer and lung cancer.
专利号:CN-107619473-A 优先权日:2016-07-13 标 题 :DMAP Removal Method in the Synthesis of Grafted Cholesterol Amphiphilic Polymer Materials