CAS: 54-03-5; Hexobendine

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    3,4,5-三甲氧基苯甲酰氯 3,4,5-Trimethoxybenzoyl Chloride 4521-61-3

    合成工艺路线路线简述

      📜N,N'-Dimethyl-N,N'-Bis(3-Hydroxypropyl)Ethylendiamin,3,4,5-三甲氧基苯甲酰氯 反应生成 海索苯定
      参考文献:ber Pharmakodynamisch Wirksame 3,4,5-Trimethoxybenzoate Und Verwandte Ester Von Symmetrischen Bis-Hydroxyalkylpiperazinen Und-Dialkylpolymethylendiaminen
      标题:ber Pharmakodynamisch Wirksame 3,4,5-Trimethoxybenzoate Und Verwandte Ester Von Symmetrischen Bis-Hydroxyalkylpiperazinen Und-Dialkylpolymethylendiaminen
      摘要:
      DOI:10.1007/bf00908805

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      专利信息


      专利号:US-10925977-B2
      优先权日:2006-10-05
      标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
      发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
      权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
      摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

      专利号:US-2005203053-A1
      优先权日:1999-07-30
      标题:Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function
      发明人:WURTMAN RICHARD J; WATKINS CAROL
      摘要:The present invention provides methods of improving a cognitive function or a neurological function, treating or ameliorating a decline in a cognitive function or a neurological function, increasing cytidine levels, or treating a neurological disorder in a subject, comprising administering a uridine, a uridine precursor, or a derivative or metabolite thereof to the subject. The invention also provides methods of improving neural function, comprising contacting the neuron with a uridine, a uridine precursor, or a derivative or metabolite thereof.

      专利号:US-10814013-B2
      优先权日:2006-10-05
      标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

      专利号:AU-2007308022-A2
      优先权日:2006-10-05
      标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

      专利号:AU-2007308022-A1
      优先权日:2006-10-05
      标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

      专利号:US-2008107598-A1
      优先权日:2006-10-05
      标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications

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      ✅ COA系统入驻 | 共享模式

      主要参考文献


      1: Kolassa N, Dŏrr B, Pfleger K. [Studies on the pharmacokinetics of hexobendine in rats. I. Distribution following i.v. administration (author's transl)]. Arzneimittelforschung. 1975 Sep;25(9):1414-7. German.
      4: Plagemann PG, Kraupp M. Inhibition of nucleoside and nucleobase transport and nitrobenzylthioinosine binding by dilazep and hexobendine. Biochem Pharmacol. 1986 Aug 1;35(15):2559-67. Japanese. German. Japanese. Italian. German.
      13: Satchell DG, Lynch A, Bourke PM, Burnstock G. Potentiation of the effects of exogenously applied ATP and purinergic nerve stimulation on the guinea-pig taenia coli by dipyridamole and hexobendine. Eur J Pharmacol. 1972 Sep;19(3):343-50. German. German. Review.
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