CAS: 41340-36-7; 2-(7-Ethyl-1H-Indol-3-yl)Ethanol

上下游产品

CAS号1191-99-7 2,3-二氢呋喃 | CAS号19398-06-2 2-乙基苯肼 盐酸盐 | CAS号25714-71-0 4-羟基丁醛 | CAS号79183-65-6 7-乙基-1H-吲哚-2,3-二酮 | CAS号13436-46-9 2-乙氧基四氢呋喃 | CAS号114737-75-6 7-ETHYLTRYPTOPHOL | CAS号41340-25-4 依托度酸 | CAS号101901-06-8 6-羟基依托度酸 | CAS号114737-75-6 7-ETHYLTRYPTOPHOL | CAS号200880-27-9 2-[(1R)-1,8-die...

7-乙基-1H-吲哚-2,3-二酮置于吡啶,硼烷四氢呋喃络合物,溶剂黄146体系中,用 四氢呋喃,乙醇 作为反应溶剂,化学反应生成 7-乙基-3-羟乙基吲哚
参考文献:A Versatile Synthetic Methodology For The Synthesis Of Tryptophols
标题:A Versatile Synthetic Methodology For The Synthesis Of Tryptophols
摘要:Tryptophols Have Been Obtained In High Yields By The Reduction Of 3-Substituted-Dioxindoles (Obtained By The Aldol Condensation Reaction Of Ketones With Isatins Or By A Modified Knovenagel Malonate Condensation) Using A Borane Tetrahydrofuran Complex. The Reported Methodology Offers Distinct Advantages Over Existing Methods For The Synthesis Of These Compounds,Including Consistently Greater Yields,Diastereoselective Syntheses And The Possibility For The Synthesis Of A Wide Range Of Structurally Different Tryptophols. The Reduction Reaction Was Found To Proceed Via An Intermediate 1,3-Diol-Oxindole,Which Was Obtained Diastereoselectively And,Which Was Subsequently Reduced To The Corresponding Tryptophol. (C) 2002 Elsevier Science Ltd. All Rights Reserved.
DOI:10.1016/s0040-4020(02)01048-7

专利信息

专利号:CN-106496164-B
优先权日:2016-09-30
标题 :A kind of method for continuous synthesis of dihydrofuran and separation of isomers

专利号:CN-206508895-U
优先权日:2017-01-21
标题:A kind of constant temperature stirring device for the synthesis of 7-ethyltryptol

专利号:CN-206404672-U
优先权日:2017-01-21
标 题:A multi-tube premixing device for the synthesis of 7-ethyltryptol

专利号:CN-107522649-A
优先权日:2017-08-08
标 题 :A kind of microwave-promoted continuous synthesis method of 7-ethyltryptol

专利号:CN-106496164-A
优先权日:2016-09-30
标 题 :A kind of method of dihydrofuran continuous synthesis and isomer separation

专利号:US-11046705-B1
优先权日:2020-03-18
标 题:Method for preparing etodolac methyl ester
发明人：YOU JINZONG; LI YINGFEI; QI DEQIANG; WU CHENGJIE
权利人:ZHEJIANG INTERNATIONAL STUDIES UNIV
摘要:The present invention discloses a method for preparing etodolac methyl ester, and relates to the technical field of organic synthesis. The method provided in the present invention includes the following steps: (1) raw materials are mixed and subjected to cyclization reaction at 20° C. to 25° C. to obtain a reaction solution, where the raw materials include 7-ethyltryptophol, methyl 3-oxopentanoate, trimethylhalosilane and methanol, excluding concentrated sulfuric acid, and the trimethylhalosilane is trimethylchlorosilane or trimethylbromosilane; and (2) the reaction solution is cooled to 10° C. to 15° C., and then filtered to obtain etodolac methyl ester and a mother liquor. The method provided in the present invention has a high yield, and does not use concentrated sulfuric acid that is extremely harmful and tends to cause product oxidation.