CAS: 3886-70-2; (R)-1-(Naphthalen-1-yl)Ethanamine

相似化合物

82572-04-1 42882-31-5 10420-89-0

上下游产品

(RS)-1-(1-naphthyl)ethylamine 2,2,2-trifluoroethylbutyrate (S)-4-Isopropyl-3-((R)-1-naphthalen-1-yl-ethyl)-oxazolidin-2-one amide(1S,2R,R)-cis-1-(2-Hydroxy-1,2,3,4-tetrahydro-1-naphthyl)methyl N-1-(1-naphthyl)ethylamide -2-phenylbutanamide(1R,2'S)-N-1-(1-naphthyl)ethyl-2-phenylbutanamide (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid 3-hydroxy-3-methyl-4-((R)-1-naphthalen-1-yl-ethylcarbamoyl)-butyl ester (3S,1'R)-N-(1-naphthylethyl)-3-(4-methylphenyl)butanamide (3R,1'R)-N-(1-naphthylethyl)-3-(4-methylphenyl)butanamide

1-萘乙酮置于盐酸,[rhcl2(P-Cymene)]2,Potassium Tert-Butylate,2-氨基-2-甲基-1-丙醇,异丙醇体系中,用 甲醇 用作溶剂,化学反应 3.5H,反应生成(R)-1-(1-萘基)乙胺
参考文献:通用型ru催化剂,用于芳香族和脂肪族次磺酰亚胺的不对称转移加氢
标题:通用型ru催化剂,用于芳香族和脂肪族次磺酰亚胺的不对称转移加氢
摘要:已开发出一种基于非手性,非常简单且廉价的氨基醇配体(2-氨基-2-甲基丙烷-1-醇)的高效ru催化剂,用于手性n-(叔丁基亚磺酰基)的不对称转移氢化(ath)).通过使用异丙醇作为氢源,该络合物能够催化芳香族和最具挑战性的脂肪族亚磺酰亚胺的ath.在短反应时间内(1-4小时)对芳香,杂芳和脂肪族亚磺酰基酮亚胺进行非对映选择性还原,包括空间拥塞的情况,然后对氮原子进行脱亚磺酰化,得到相应的高度对映体富集的(ee高达99%以上)的α支链伯胺,收率很高.通过在亚胺基体中使用适当的绝对构型,相同的配体对于(R)和(S)胺的合成同样有效.Dft机理研究表明,氢转移过程是逐步进行的.此外,非对映选择性的起源已被合理化.
Doi:10.1002/chem.201102426

专利信息

专利号:US-7452994-B2
优先权日:2001-09-12
标 题 :Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
发明人：MCEACHERN ERNEST J; BRIDGER GARY J; SKUPINSKA KRYSTYNA A; SKERLJ RENATO T; YANG WEN
权利人:ANORMED INC
摘要:This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.

专利号:US-2023278959-A1
优先权日:2020-05-04
标题:Synthesis of Optically Active Indoline Derivatives Via Ruthenium(II)-Catalyzed Enantioselective C-H Functionalization
发明人：CUI XIN; LI ZHONG-YUAN; CHAMINDA LAKMAL HETTI HANDI
权利人:UNIV MISSISSIPPI STATE
摘要:Provided herein are a method of Ru(II)-catalyzed enantioselective synthesis of a cyclic compound and cyclic compounds formed therefrom. The method includes providing a precursor compound having an unfunctionalized C—H bond and activating the unfunctionalized C—H bond by reacting the precursor compound in the presence of co-catalysts including a Ru(II) arene complex and a chiral transient directing group (CTDG).

专利号:US-9938509-B2
优先权日:2010-12-08
标 题 :Biocatalysts and methods for the synthesis of armodafinil
发明人：ANG EE LUI; ALVIZO OSCAR; BEHROUZIAN BEHNAZ; CLAY MICHAEL D; COLLIER STEVEN J; EBERHARD ELLEN D; FAN FU; SONG SHIWEI; SMITH DEREK J; WIDEGREN MAGNUS; WILSON ROBERT; XU JUNYE; ZHU JUN
权利人:CODEXIS INC
摘要:The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.

专利号:US-8084630-B2
优先权日:2007-05-31
标 题 :Process for the synthesis of ramelteon and its intermediates
发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL
权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL; TEVA PHARMA
摘要:The present invention provides processes and intermediates for the synthesis of ramelteon.

专利号:US-9315483-B2
优先权日:2007-09-13
标题 :Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof
发明人：JONES ANDREW D; ZELLE ROBERT E; SILVERMAN I ROBERT
权利人:CONCERT PHARMACEUTICALS INC
摘要:The present invention provides a convenient and efficient process for the synthesis of d 2 -benzo[d][1,3]dioxoles.

专利号:US-2022064111-A1
优先权日:2019-01-17
标 题:Enantioselective synthesis of brivaracetam and intermediates thereof
发明人：ROY SARABINDU; GHOSH ANGSHUMAN; KUBEER RAMESH DHONDI; PRASAD MUTYALA V V VARA; PAUL GOPAL; GARAI ABHISHEK; CHAKRABORTY SOURAV; HALDAR ANIMESH; YADAW AJAY KUMAR; ROY SUBHO
权利人:CLININVENT RES PVT LTD
摘要:The present invention relates to an improved and economical process for enantioselective synthesis and purification of a novel key intermediate of Brivaracetam. Further, the present invention also relates to a process for the preparation of a chirally pure Brivaracetam of formula I utilizing the said intermediate.