专利号:US-9597327-B2 优先权日:2005-05-25 标 题:Synthesis of (R)-N-methylnaltrexone 发明人:DOSHAN HAROLD D; PEREZ JULIO 权利人:PROGENICS PHARM INC 摘要:This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.
专利号:US-2024082118-A1 优先权日:2021-05-19 标 题:Topical compositions and methods of preparing the same 发明人:ABRAMOVICH SAGI; AVIDOR GAL; LANDA BENZION 权利人:LANDA LABS 2012 LTD 摘要:There is disclosed a composition comprising a water-insoluble thermoplastic compound capable of stimulating collagen synthesis (CSSC), the CSSC having a molecular weight of more than 0.6 kDa and being dispersed in a polar carrier as nano-elements having an average diameter of 200 nm or less and a viscosity of 107 mPa·s or less. The nano-elements of CSSC can be capable of stimulating the synthesis of skin proteins and/or enabling the delivery of active agents upon their application to a surface to be treated therewith. Methods for preparing the compositions and uses thereof are also provided.
专利号:US-9757317-B2 优先权日:2014-09-12 标题 :Cosmetic compositions and methods for inhibiting melanin synthesis 发明人:LAUGHLIN II LEO TIMOTHY; HAKOZAKI TOMOHIRO; GUPTA SHIKHAR 权利人:PROCTER & GAMBLE 摘要:A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include bisabolol, undecylenoyl phenylalanine and/or hexyldecanol, and a material selected from the group consisting of ethyl palmitate, stearyl alcohol, bis (2-ethylhexyl) adipate, bis (2-ethylhexyl) maleate, 5-pentadecanol, 1-stearoyl-rac-glycerol, bis (2-ethylhexyl) sebacate, and mixtures thereof. A method of reducing the synthesis of melanin by using the cosmetic compositions is also disclosed herein.
专利号:US-2012094919-A1 优先权日:2009-03-16 标题 :Use of tripeptides 发明人:GRAEUB REMO; HEIDL MARC; IMFELD DOMINIK; MUELLER EIKE; WIKSTROEM PETER; ZIEGLER HUGO 权利人:GRAEUB REMO; HEIDL MARC; IMFELD DOMINIK; MUELLER EIKE; WIKSTROEM PETER; ZIEGLER HUGO 摘要:The present invention relates to the use of tripeptide derivatives for tightening, firming and/or moisturizing skin. Furthermore, the invention relates to a method for stimulating the synthesis of glycosaminoglycans containing a D-glucosamine and/or N-acetyl-D-glucosamine residue and/or proteoglycans by fibroblasts and/or keratinocytes such as in particular the synthesis of Hyaluronic acid and/or of the proteoglycans Decorin and/or Lumican.
专利号:US-9498420-B2 优先权日:2013-05-01 标 题:Cosmetic compositions and methods for inhibiting melanin synthesis 发明人:LAUGHLIN II LEO TIMOTHY; HAKOZAKI TOMOHIRO; TANAKA SHUHEI 权利人:PROCTER & GAMBLE 摘要:A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include batyl alcohol, undecylenoyl phenylalanine, hexyldecanol, and bisabolol. A method of reducing the synthesis of melanin by using the cosmetic compositions is also disclosed herein.
专利号:EP-1721601-A1 优先权日:2005-05-11 标 题 :Use of taurine for enhancing lipid synthesis in the epidermis 发明人:DOERING THOMAS; WALDMANN-LAUE MARIANNE; WADLE ARMIN; ANDERHEGGEN BERND 权利人:HENKEL KGAA 摘要:The present invention is the use of taurine for stimulating the epidermal synthesis of barrier lipids.
1: Yu D, Hornung E, Iven T, Feussner I. High-level accumulation of oleyl oleate in plant seed oil by abundant supply of oleic acid substrates to efficient wax ester synthesis enzymes. Biotechnol Biofuels. 2018 Mar 1;11:53. doi: 10.1186/s13068-018-1057-4. 2: de Jong A, Cheng TY, Huang S, et al. CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens. Nature Immunology. 2014 Feb;15(2):177-185. DOI: 10.1038/ni.2790. 3: Kalscheuer R, Stöveken T, Luftmann H, et al. Neutral lipid biosynthesis in engineered Escherichia coli: jojoba oil-like wax esters and fatty acid butyl esters. Applied and Environmental Microbiology. 2006 Feb;72(2):1373-1379. DOI: 10.1128/aem.72.2.1373-1379.2006.
合成参考文献
摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118 摘要:International Journal of Toxicology 34(Suppl.2):5-69, 2015