CAS: 3541-42-2; 3-(2-Hydroxyphenyl)Acrylaldehyde

上下游产品

2-羟基肉桂酸 2-Hydroxycinnamic Acid 583-17-5
2-羟基肉桂醇 2-Hydroxycinnamyl Alcohol 51764-86-4
3-(2-羟基苯基)-丙烯酸甲酯 Methyl 2-Coumarate 20883-98-1
3-(2'-O-Acetylphenyl)-2-Propenal 33538-94-2

2-羟基肉桂酸置于manganese(Iv) Oxide,二异丁基氢化铝体系中,用 四氢呋喃,甲醇,二氯甲烷,丙酮 用作溶剂,化学反应生成2-羟基肉桂醛
参考文献:Synthesis And Biological Activity Of Cinnamaldehydes As Angiogenesis Inhibitors
标题:Synthesis And Biological Activity Of Cinnamaldehydes As Angiogenesis Inhibitors
摘要:A Series Of 2-Hydroxycinnamaldehyde Derivatives Was Synthesized For Examing A Structure-Activity Relationship For Inhibition Of Angiogenesis. The Anti-Angiogenic Effects Of 2'-Substituted Cinnamaldehdes And Related Analogs Were Determined In A Chick Embryo Chorioallantoic Membrane Assay System. (C) 1997 Elsevier Science Ltd.
Doi:10.1016/s0960-894X(97)10008-7

专利信息

专利号:US-2012095211-A1
优先权日:2010-09-22
标 题 :Substituted proline inhibitors of hepatitis c virus replication
发明人：BUCKMAN BRAD; NICHOLAS JOHN B; SEREBRYANY VLADIMIR; SEIWERT SCOTT D
权利人:BUCKMAN BRAD; NICHOLAS JOHN B; SEREBRYANY VLADIMIR; SEIWERT SCOTT D; INTERMUNE INC
摘要:The embodiments provide compounds of the general Formulae I, Ia, II, IIa, III, IIIa, IIIb, IV, IVa, IVb, V, Va, Vb, VI, VIa, VIb, and VIc, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. The embodiments also provide methods for the synthesis of subject compounds and intermediates in the synthetic methods.

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