专利号:US-3644427-A 优先权日:1970-02-13 标 题:Synthesis of 3-haloalkyl hydrocarboncarboxylates and 4-halotetrahydropyrans 发明人:STAPP PAUL R 权利人:PHILLIPS PETROLEUM CO 摘要:A 3-HALOALKY HYDROCARBONCARBONXYLATE AND A 4-HALOTETRAHYDROPYRAN ARE PRODUCED BY REACTING A 1-ALKENE, (HCHO)N'' A HYDROGEN HALIDE AND AN ACID HALIDE AT A TEMPERATURE IN THE RANGE OF -80 TO -30* C., WHEREIN N IS THE INTEGER 1 OR GREATER.
专利号:WO-2010096722-A1 优先权日:2009-02-20 标 题 :3-oxo-2, 3-dihydro- [1,2, 4] triazolo [4, 3-a]pyridines as soluble epoxide hydrolase (seh) inhibitors 发明人:FENG JUN; KEUNG WALTER; NOTZ WOLFGANG REINHARD LUDWIG 权利人:TAKEDA PHARMACEUTICAL; FENG JUN; KEUNG WALTER; NOTZ WOLFGANG REINHARD LUDWIG 摘要:Claimed are intermediates in the synthesis of N-Arylmethyl-3-Oxo-2,3-dihydro- [1,2,4]triazolo[4,3-a]pyridine-6-carboxamides as well as a process (A) to arrive at 3-Oxo-2, 3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid. The triazolo[4,3-a]pyridine-6-carboxamides of formula (I) are used as soluble epoxide hydrolase inhibitors (sEH) having therapeutic effect in pathologic conditions such as hypertension, stroke, inflammatory processes, diabetes and a variety of cardiovascular diseases.
专利号:US-9051289-B2 优先权日:2013-09-26 标 题 :Process and intermediates for preparing GPR40 agonists 发明人:DAHMANN GEORG; WAGNER HOLGER; ECKHARDT MATTHIAS; FRANK MARKUS; SANTAGOSTINO MARCO; SCHNAUBELT JUERGEN; STERTZ UWE; PACHUR THORSTEN 权利人:DAHMANN GEORG; WAGNER HOLGER; ECKHARDT MATTHIAS; FRANK MARKUS; SANTAGOSTINO MARCO; SCHNAUBELT JUERGEN; STERTZ UWE; PACHUR THORSTEN; BOEHRINGER INGELHEIM INT 摘要:The present invention relates to compounds of formula I n nwherein R S denotes F or CF 3 , R a denotes H or C 1-4 -alkyl and Z denotes a leaving group or an optionally substituted or protected hydroxyl group, suitable as intermediates in the synthesis of indanyloxydihydrobenzofuranylacetic acids, which are GPR40 agonists, to a process for preparing these intermediates and to the process for preparing the GPR40 agonists making use of an asymmetric catalytic hydrogenation reaction in the presence of a transition metal catalyst and a chiral auxiliary.
专利号:US-2023357177-A1 优先权日:2020-12-17 标题:Synthesis of cannabidiol and analogs thereof, and related compounds, formulations, and methods of use
专利号:CN-108689976-A 优先权日:2018-07-23 标 题:Catalytic Synthesis of 4-Iodotetrahydropyran Derivatives Catalyzed by 5-Sulphosalicylic Acid and Titanocene Dichloride
专利号:CN-108689976-B 优先权日:2018-07-23 标题 :A method for the synthesis of 4-iodotetrahydropyran derivatives catalyzed by 5-sulfosalicylic acid in conjunction with dichlorotitanocene