CAS: 247564-72-3; 2,4,5-Trifluorophenylboronic Acid

上下游产品

1-bromo-2,4,5-trifluorobenzene 2-chloro-4-fluoro-6-(2,4,5-trifluorophenyl)pyrimidine

2,4,5-三氟溴苯置于正丁基锂,硼酸三甲酯体系中,用 正己烷 用作溶剂,化学反应 1.0H,以70%的收率获得2,4,5-三氟苯硼酸
参考文献:多氟联苯的合成;推动铃木-宫浦交叉耦合与电子贫乏基板的边界
标题:多氟联苯的合成;推动铃木-宫浦交叉耦合与电子贫乏基板的边界
摘要:多氟联苯是许多不同应用中令人感兴趣且有希望的基材.不幸的是,目前用于合成这些化合物的所有方法仅适用于充满分子的手或仅在非常特殊的情况下.因此,迄今仍无法获得许多这些化合物.在这里,我们报告了合成各种高度氟化联苯的一般策略.在我们的研究中,我们研究了关键参数,例如不同的膦配体以及具有不同氟化度的各种亲核试剂和亲电试剂的影响.这些结果将已经非常通用的suzuki-Miyaura反应的范围扩展到了电子贫乏产品的合成上,使这些产品更容易获得.
Doi:10.1021/acs.Joc.7B02267

专利信息

专利号:US-2025304580-A1
优先权日:2021-11-09
标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK; KAPLAN ALAN P; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?).This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-12319691-B2
优先权日:2020-05-04
标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：CZABANIUK LARA C; HOPPER TIMOTHY; HOUZE JONATHAN B; RESCOURIO GWENAELLA; SANTORA VINCENT; WANG HAOXUAN; WHITE RYAN D; WONG ALICE R; WU YONGWEI
权利人:AMGEN INC; VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?).This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-12428425-B2
优先权日:2020-05-04
标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：CZABANIUK LARA C; HOPPER TIMOTHY; HOUZE JONATHAN B; PANTELEEV JANE; RESCOURIO GWENAELLA; SANTORA VINCENT; WANG HAOXUAN; WHITE RYAN D; WONG ALICE R; WU YONGWEI; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN
权利人:AMGEN INC; VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?).This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:CN-117486916-A
优先权日:2023-12-29
标题:A kind of synthesis method of 3,4,5-trifluorobenzene boric acid

专利号:CN-115819260-B
优先权日:2022-11-28
标 题:A kind of synthesis process of sitagliptin intermediate

专利号:CN-117486916-B
优先权日:2023-12-29
标题:A kind of synthesis method of 3,4,5-trifluorophenylboric acid