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2,2,4,4-tetramethyl-3-nitroso-3-chloropentane trimethylaluminumN-tert-butylacetamide 2-bromo-3,3-dimethyl-2-nitroso-butane 2,2-dimethyl-1-methylpropylamine 15H23ClNO2PSC15H23ClNO2PS 专利信息
专利号:US-9707301-B2
优先权日:2011-10-14
标题 :Pyrrolobenzodiazepines and targeted conjugates
发明人:JEFFREY SCOTT; BURKE PATRICK; HOWARD PHILIP WILSON
权利人:SEATTLE GENETICS INC; MEDIMMUNE LTD
摘要:This invention relates to pyrrolobenzodiazepines (PBDs), in particular pyrrolobenzodiazepine dimers having a C2-C3 double bond and an aryl group at the C2 position in each monomer unit, and their inclusion in targeted conjugates. The differing substituent groups may offer advantages in the preparation and use of the compounds, particularly in their biological properties and the synthesis of conjugates, and the biological properties of these conjugates.
专利号:WO-9918065-A1
优先权日:1997-10-03
标 题:Chiral amines
发明人:JOHNSON NICHOLAS BERNARD; BURK MARK JOSEPH; CASY GUY
权利人:CHIROTECH TECHNOLOGY LTD
摘要:An efficient synthesis of chiral amines (5) comprises preparing an enamide (4) from the oxime (2), and subjecting the enamide to catalytic asymmetric hydrogenation.
专利号:US-11801242-B2
优先权日:2018-10-09
标 题:Compositions and methods for adjuvant cancer therapeutics
发明人:ZHOU PEI; HONG JIYONG
权利人:UNIV DUKE
摘要:This invention relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases related to translesion synthesis (TLS) pathway. More particularly, this disclosure relates to small molecule inhibitors of TLS, methods of inhibiting TLS pathway with these compounds, and methods of treating diseases related to the TLS pathway.
专利号:CN-109399589-A
优先权日:2018-12-21
标题:A kind of continuous synthesis method of hydroxylamine hydrochloride
专利号:CN-109399589-B
优先权日:2018-12-21
标 题:Continuous synthesis method of hydroxylamine hydrochloride