CAS: 17946-87-1; Leucomisine

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16H20O7SC16H20O7S 1,10-epoxy-8α-hydroxyachillin (1S,2S,6S)-9,13-dimethyl-5-methylene-3-oxatricyclo[8.3.0.0(2,6)]trideca-9,12-diene-4,11-dione1α,10α-epoxydesacetoxymatricarin

📜(3As,9As,9Bs)-6,9-二甲基-3-亚甲基-4,5,9A,9B-四氢-3Ah-薁并[5,4-D]呋喃-2,7-二酮置于sodium Tetrahydroborate体系中,化学反应生成Achillin,去乙酰氧母菊素
参考文献:The Effect Of Dehydroleucodine In Adipocyte Differentiation
标题:The Effect Of Dehydroleucodine In Adipocyte Differentiation
摘要:Dehydroleucodine (Dhl) Is A Sesquiterpene Lactone Of The Guaianolide Group With Gastric Cytoprotective Activity. Recent Studies Have Also Demonstrated That Dhl Inhibits The Proliferation Of Vascular Smooth Muscle Cells. In This Study We Examined The Effect Of Dhl In The Differentiation Of 3T3-L1 Preadipocytes. The Addition Of Dhl Significantly Inhibited The Differentiation Of 3T3-L1 Preadipocytes Along With A Significant Decrease In The Accumulation Of Lipid Content By A Dramatic Downregulation Of The Expression Of Adipogenic-Specific Transcriptional Factors Ppar Gamma And C-Ebp Alpha. However,Phosphorylation Of Ampk Alpha,Erk1/2 And Akt1 Was Not Inhibited By Dhl Treatment. Interestingly,We Also Found That 11,13-Dihydrodehydroleucodine,A Derivative Of Dhl With Inactivated Alpha-Methylene-Gamma-Lactone Function,Also Inhibited The Differentiation Of 3T3-L1 Preadipocytes. Taken Together,These Data Suggest That Dhl Has An Important Inhibitory Effect In Cellular Pathways Regulating Adipocyte Differentiation By Modulating The Ppar Gamma Expression,Which Is Known To Play A Pivotal Role During Adipogenesis. (C) 2011 Elsevier B.V. All Rights Reserved.
Doi:10.1016/j.Ejphar.2011.09.033