CAS: 175357-18-3; (S)-3-Phenyl-2-(Undec-10-Enamido)Propanoic Acid

上下游产品

undec-10-enoyl chloride L-phenylalanine 10-undecenoic acid

2-十一烯酸,L-苯丙氨酸置于aminoacylases From Streptomyces Ambofaciens,Cobalt(II) Chloride体系中,用 Aq. Buffer 用作溶剂,化学反应生成十一碳烯酰基苯丙氨酸
参考文献:来自 Streptomyces Ambofaciens 的氨基酰化酶催化 N-10-十一烯酰基-苯丙氨酸的酶促合成
标题:来自 Streptomyces Ambofaciens 的氨基酰化酶催化 N-10-十一烯酰基-苯丙氨酸的酶促合成
摘要:摘要 由于其物理化学和生物活性,N-10-十一碳烯酰苯丙氨酸 (C11'F) 是化妆品和制药行业中最有趣的脂族氨基酸之一.它的生产目前基于 Schotten-Baumann 化学反应,这表明在流出物方面存在一些环境问题.作为一种可能的生物催化替代方案,本研究评估了允许使用来自 Streptomyces Ambofaciens 培养物的氨酰酶生产 C11'F 的反应和工艺条件.这些氨基酰化酶在 45oc 和 Ph 值介于 7 和 8 之间时表现出最佳活性,具有中等热稳定性.底物浓度对 C11'F 合成动力学参数的影响表明,与 10-十一碳烯酸浓度相比,苯丙氨酸浓度的影响更为重要.作为反应产物,C11'F 似乎对酶促 N-酰化具有抑制作用.添加钴使反应速率提高了 11 倍.间歇反应器与游离氨基酰化酶一起使用,对最终的 C11'F 浓度没有影响.第一次,酶促生产的 C11'F 最终以克级规模纯化为
Doi:10.1016/j.Procbio.2020.09.009

专利信息

专利号:US-9757317-B2
优先权日:2014-09-12
标题 :Cosmetic compositions and methods for inhibiting melanin synthesis
发明人：LAUGHLIN II LEO TIMOTHY; HAKOZAKI TOMOHIRO; GUPTA SHIKHAR
权利人:PROCTER & GAMBLE
摘要:A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include bisabolol, undecylenoyl phenylalanine and/or hexyldecanol, and a material selected from the group consisting of ethyl palmitate, stearyl alcohol, bis (2-ethylhexyl) adipate, bis (2-ethylhexyl) maleate, 5-pentadecanol, 1-stearoyl-rac-glycerol, bis (2-ethylhexyl) sebacate, and mixtures thereof. A method of reducing the synthesis of melanin by using the cosmetic compositions is also disclosed herein.

专利号:US-9498420-B2
优先权日:2013-05-01
标 题:Cosmetic compositions and methods for inhibiting melanin synthesis
发明人：LAUGHLIN II LEO TIMOTHY; HAKOZAKI TOMOHIRO; TANAKA SHUHEI
权利人:PROCTER & GAMBLE
摘要:A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include batyl alcohol, undecylenoyl phenylalanine, hexyldecanol, and bisabolol. A method of reducing the synthesis of melanin by using the cosmetic compositions is also disclosed herein.

专利号:EP-2271614-A2
优先权日:2008-03-28
标 题:Method for the continuous synthesis of an n-acylated compound, and equipment for implementing said method

专利号:WO-2009118493-A2
优先权日:2008-03-28
标题 :Method for the continuous synthesis of an n-acylated compound, and equipment for implementing said method

专利号:FR-2929275-A1
优先权日:2008-03-28
标题:PROCESS FOR THE CONTINUOUS SYNTHESIS OF AN N-ACYL COMPOUND INSTALLATION FOR IMPLEMENTING THE METHOD

专利号:US-2011236330-A1
优先权日:2008-12-09
标 题:Skin Whitening
发明人：MOUSSOU PHILIPPE; SABADOTTO MELANIE; RATHJENS ANDREAS
权利人:MOUSSOU PHILIPPE; SABADOTTO MELANIE; RATHJENS ANDREAS
摘要:Methods for reducing pigmentation or hyperpigmentation of skin comprising applying to the skin a substance of formula (I) in the D-form, L-form or racemic form (D,L) are disclosed: n n n n n n n n n n whereinn R 1 is selected from the group consisting of a hydrogen group (—H), a methyl group (—CH 3 ), an ethyl group (—CH 2 CH 3 ), a C3 alkyl group, a C4 alkyl group, an acetyl group (—C(O)CH 3 ), a propanoyl group (—C(O)CH 2 CH 3 ), an n-butanoyl group (—C(O)CH 2 CH 2 CH 3 ), and a 2-methyl-propanoyl group (—C(O)CH(CH 3 ) 2 ), R 2 is selected from the group consisting of a hydrogen group (—H), an ethyl group (CH 2 CH 3 ), a C3 alkyl group, a C4 alkyl group, an acetyl group (—C(O)CH 3 ), a propanoyl group (—C(O)CH 2 CH 3 ), an n-butanoyl group (—C(O)CH 2 CH 2 CH 3 ), and a 2-methyl-propanoyl group (—C(O)CH(CH 3 ) 2 ), R 3 is selected from the group consisting of a hydroxyl group (—OH), an amino group (NH 2 ), a methoxy group (OCH 3 ), an ethoxy group (—OCH 2 CH 3 ), a C3 alkoxy group, a C4 alkoxy group, and a benzyloxy group (—OCH 2 C 6 H 5 ), and X and Y are independently selected from the group consisting of a hydrogen group (—H), a methyl group (—CH 3 ), an ethyl group (—CH 2 CH 3 ), a C3 group alkyl, a C4 alkyl group, a halogen group, a methoxy group (—OCH 3 ), an ethoxy group (—OCH 2 CH 3 ), a C3 alkoxy group, a C4 alkoxy group, and a benzyloxy group (—OCH 2 C 6 H 5 ), provided that at least one of X and Y is not a hydrogen group (—H). nn Cosmetic compositions and/or topical compositions comprising the substance are useful for (i) lightening of the skin and/or (ii) whitening of the skin and/or (iii) reduction of pigmentation of the skin and/or (iv) reduction of hyperpigmentation of the skin and/or (v) inhibition of melanogenesis in the skin and/or (vi) prevention and/or retardation of signs of ageing and/or improving the skin appearance of an aged skin. Such composition are also useful for treatment of pigmentation or hyperpigmentation of the skin due to abnormal melanin synthesis and/or secretion.