专利号:US-9700589-B2 优先权日:2015-02-03 标题:Compositions and methods for improved muscle metabolism 发明人:BILY ANTOINE CHARLES; MEYER MARJOLAINE; CHEVALIER KARL; Laurençon Lise; FEUILLERE NICOLAS; ROLLER MARC; BIRTIC SIMONA 权利人:NATUREX SA 摘要:A composition for improving muscle metabolism in a subject and methods for manufacturing and using same. Embodiments include compositions having an extract of Rhaponticum and an extract of Rhodiola . An extract of Rhaponticum may include amounts of ecdysterones including 20-hydroxyecdysone. An extract of Rhodiola my include salidrosides and rosavins, including rosavin. Suitable ingestion dosages of the composition may be operable to increase protein synthesis and reduce protein proteolysis in a subject.
1: Lu X, Qiu H, Yang L, Zhang J, Ma S, Zhen L. Anti-proliferation effects, efficacy of cyasterone in vitro and in vivo and its mechanism. Biomed Pharmacother. 2016 Dec;84:330-339. doi: 10.1016/j.biopha.2016.09.041. Epub 2016 Sep 23. doi: 10.1002/bmc.3621. Epub 2015 Nov 17. doi: 10.1021/jo5005108. Epub 2014 Jun 4. Epub 2005 Feb 24.
合成参考文献
参考文献:10.1002/ps.2203 摘要:Aly R, Ravid U, Abu‐Nassar J, Botnick I, Lebedev G, Gal S, Ziadna H, Achdari G, Smirov E, Meir A, Ghanim M. Biological activity of natural phytoecdysteroids from Ajuga iva against the sweetpotato whitefly Bemisia tabaci and the persea mite Oligonychus perseae. Pest Management Science. 2011 May 20;67(12):1493–8. doi: 10.1002/ps.2203. 参考文献:10.1021/np800131f 摘要:Castro A, Coll J, Tandrón YA, Pant AK, Mathela CS. Phytoecdysteroids from Ajuga macrosperma var. breviflora Roots. J. Nat. Prod. 2008 Jun 05;71(7):1294–6. doi: 10.1021/np800131f.