CAS: 156545-07-2; 3,5-Difluorophenylboronic Acid

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CAS号121-43-7 硼酸三甲酯 | CAS号461-96-1 1-溴-3,5-二氟苯 | CAS号1435-43-4 1-氯-3,5-二氟苯 | CAS号5419-55-6 硼酸三异丙酯 | CAS号401-85-4 3,5-二氟三氟甲基苯 | CAS号155366-02-2 8-(3,5-difluoro... | CAS号216393-57-6 3,5-二氟苯硼酸新戊基乙醇酯 | CAS号2713-34-0 3,5-二氟苯酚 | CAS号2265-91-0 3,5-二氟碘苯 | CAS号857048-78-3 2,3,5-三氟-4-丙基三联苯 | CAS号866108-77-2 2-(3',5'-二氟-[1,... | CAS号867208-91-1 methyl 6-(3,5-d... | CAS号41860-52-0 1-(3,5-difluoro... | CAS号500229-85-6 2-(3,5-difluoro...

1-溴-3,5-二氟苯置于magnesium,硼酸三甲酯,盐酸体系中,用 乙醚 用作溶剂,化学反应生成3,5-二氟苯硼酸
参考文献:(Fluoroorgano)Fluoroboranes And-Fluoroborates I: Synthesis And Spectroscopic Characterization Of Potassium Fluoroaryltrifluoroborates And Fluoroaryldifluoroboranes
标题:(Fluoroorgano)Fluoroboranes And-Fluoroborates I: Synthesis And Spectroscopic Characterization Of Potassium Fluoroaryltrifluoroborates And Fluoroaryldifluoroboranes
摘要:A Convenient Preparation Of K[arbf3] (Ar= 2-C6H4F,3-C6H4F,4-C6H4F,2,6-C6H3F2,3,5-C6H3F2,2,4,6-C6H2F3,3,4,5-C6H2F3,2,3,4,5-C6Hf4 And C6F5) Is Offered And The Ir And Multinuclear NMR Spectra Of These Salts Are Reported. Treatment Of The Trifluoroborate Salts With Bf3 In Chlorocarbon Solvents Provides An Easy Synthetic Route To The Corresponding Aryldifluoroboranes Arbf2. The Multinuclear NMR Spectra Of Arbf2 Are Presented. The Electron Substituent Effect Of The [-Bf3](-)-Group Shows This Substituent As One Of The Strongest Sigma-Electron Donors,While Its Pi-Electron Influence Is Negligible (Sigma(I) =-0.32,Sigma(R) =-0.07). (C) 2000 Elsevier Science S.A. All Rights Reserved.
Doi:10.1016/s0022-328X(99)00690-7

专利信息

专利号:US-12150934-B2
优先权日:2016-11-30
标 题 :Methods of using substituted pyrazole and pyrazole compounds and for treatment of hyperproliferative diseases
发明人：SIDDIQUI ARSHAD M; CIBLAT STEPHANE; CONSTANTINEAU-FORGET LEA; GRAND-MAITRE CHANTAL; GUO XIANGYU; SRIVASTAVA SANJAY; SHIPPS GERALD W; COOPER ALAN B; OZA VIBHA; KOSTURA MATTHEW W; LUTHER MICHAEL; LEVINE JEDD
权利人:BANTAM PHARMACEUTICAL LLC
摘要:Disclosed are methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formula (I), in which X1, X2, Z1, Z2, the ring system denoted by “aâ€?, R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.

专利号:US-2009306392-A1
优先权日:2007-10-19
标题 :Gsm intermediates
发明人：HO CHIH YUNG
权利人:HO CHIH YUNG
摘要:The present invention relates the use of compounds having the general Formula I, wherein the definitions or R 1 and R 2 are provided in the specification. Said compounds of Formula I are useful for the synthesis of a variety of γ-secretase modulators, which are in turn useful for the treatment of diseases associated with γ-secretase activity, including Alzheimer's disease.

专利号:WO-2006079916-A1
优先权日:2005-01-26
标 题 :Thieno [2,3-d] pyrimidine compounds as inhibitors of adp-mediated platelets aggregation
发明人：ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; RAHMAN HAYAT; SCHWEITZER BARBARA ANN; TENBRINK RUTH ELIZABETH
权利人:PHARMACIA & UPJOHN CO LLC; ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; RAHMAN HAYAT; SCHWEITZER BARBARA ANN; TENBRINK RUTH ELIZABETH
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I): wherein A1, A2, A3, A4, A5, A6, A7, A8, X4, X6, R2, R4, R5, and R6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-7781470-B2
优先权日:1999-09-13
标题:Aminodicarboxylic acid derivatives having pharmaceutical properties
发明人：ALONSO-ALIJA CRISTINA; HEIL MARKUS; FLUBACHER DIETMAR; NAAB PAUL; PERNERSTORFER JOSEF; STASCH JOHANNES-PETER; WUNDER FRANK; DEMBOWSKY KLAUS; PERZBORN ELIZABETH; STAHL ELKE
权利人:BAYER SCHERING PHARMA AG
摘要:The invention relates to compounds of formulae (II), (IV), and (VI) as shown below, n nwherein the several variable groups are as defined in the specification and claims. Processes for making these materials, and methods for using them in the synthesis of compounds for treatment of cardiovascular disorders and fibrotic disorders are also disclosed.

专利号:CN-113402412-A
优先权日:2021-06-10
标题 :(E) Synthesis of β-fluoroacrylamide derivatives

专利号:US-2009137557-A1
优先权日:2005-11-22
标题 :Calcilytic Compounds
发明人：KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S
权利人:KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S
摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.