CAS: 129540-24-5; 2-(2-Bromophenyl)Pyrrolidine
该化合物是一种溴化丙烯衍生物,在2位置上具有苯替代成分,是有机合成的多用途中间体,其结构特征,包括溴原子和丙烯环等,使得它对于诸如铃木或Buchwald-Hartwig等交叉反应具有价值,从而能够构建复杂的环环状框架.该化合物的僵硬芳香系统和含氮环增强了其在制药和农用化学研究中的效用,特别是在生物活性分子的开发方面.高纯度和一贯的质量确保了合成应用的可靠性能.由于溴杂质可能具有再活动性,因此建议适当处理.
相似化合物
1197232-93-1 1217680-27-7 1217757-46-4物理性质
MSDS等安全信息
合成工艺路线路线简述
- 合成目标产物 2-(2-Bromophenyl)Pyrrolidine 主要起始原料 5-(2-Bromophenyl)-3,4-Dihydro-2H-Pyrrole
- (文献来源)合成步骤主要原料 5-(2-Bromophenyl)-3,4-Dihydro-2H-Pyrrole
📜2-(2-Bromophenyl)-1-Pyrroline置于sodium Tetrahydroborate,溶剂黄146,盐酸,水,Sodium Hydroxide体系中,用 甲醇,水 用作溶剂,化学反应生成2-(2-溴苯基)-吡咯烷
参考文献:(Pyrrolidin-2-yl)Phenyl Derivatives
标题:(Pyrrolidin-2-yl)Phenyl Derivatives
摘要:该发明涉及具有通式i的(吡咯啉-2-基)苯基衍生物,其中r1为(c1-4)烷基,卤代(c1-4)烷基,(c1-4)烷氧基或卤代(c1-4)烷氧基;R2为h,(c1-4)烷基,卤代(c1-4)烷基,(c1-4)烷氧基,卤代(c1-4)烷氧基或卤素;R3为h,(c1-4)烷基或卤代(c1-4)烷基;R4为h,(c1-4)烷基或卤代(c1-4)烷基;R5为h,(c1-4)烷基或卤代(c1-4)烷基;或者当r4和r5与同一碳原子结合时,它们可以与碳原子一起形成一个可选择地取代卤素的螺环(c3-6)环烷基基团;R6为h,(c1-4)烷基,卤代(c1-4)烷基,(c1-4)烷氧基,卤代(c1-4)烷氧基或卤素;或其药学上可接受的盐,以及含有这些(吡咯啉-2-基)苯基衍生物的药物组合物,以及这些(吡咯啉-2-基)苯基衍生物用于治疗疼痛,如神经痛或炎症性疼痛.
海关参考信息
- 2902600000-乙苯
2921199090-其他无环单胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2022073513-A1
优先权日:2018-12-29
标题:1h-pyrrolo[2,3-b]pyridine derivatives and related compounds as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases
发明人：CHEN YI
权利人:NEWAVE PHARMACEUTICAL INC
摘要:The present invention relates to compounds of Formula (II) and more preferably to 1H-pyrrolo[2,3-b]pyridine derivatives of formula (III) and related compounds. The variables are defined in the claims. The compounds are BCL-2 inhibitors for treating neoplastic, autoimmune or neurodegenerative diseases. The present description discloses the synthesis of exemplary compounds as well as pharmacological data thereof (pages 61 to 72; examples 1 to 4; tables). An exemplary compound is e.g. 4-(4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl]piperazin-1-yl)-2-[methyl(1H-pyrrolo[2,3-b]pyridin-5-yl)phosphoroso]-N-[3-nitro-4-[(oxan-4-yl methyl)amino]benzenesulfonyl]benzamide (example 1).
专利号:US-2023119463-A1
优先权日:2019-12-27
标题 :1h-pyrrolo[2,3-b]pyridine derivatives as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases
发明人：CHEN YI
权利人:NEWAVE PHARMACEUTICAL INC
摘要:The present invention relates to 1H-pyrrolo[2,3-b]pyridine derivatives and related compounds as BCL-2 inhibitors for treating neoplastic, autoimmune or neurodegenerative diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 162 to 233; examples 1 to 8; table; compound examples cpd-1 to cpd-135; biological examples 1 to 4).
专利号:WO-2021133817-A1
优先权日:2019-12-27
标题 :1h-pyrrolo[2,3-b]pyridine derivatives as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases
发明人：CHEN YI
权利人:GUANGZHOU LUPENG PHARMACEUTICAL COMPANY LTD; NEWAVE PHARMACEUTICAL INC
摘要:The present invention relates to lH-pyrrolo[2,3-b]pyridine derivatives and related compounds as BCL-2 inhibitors for treating neoplastic, autoimmune or neurodegenerative diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 162 to 233; examples 1 to 8; table; compound examples cpd-1 to cpd-135; biological examples 1 to 4).
