CAS: 99-91-2; 1-(4-Chlorophenyl)Ethanone

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CAS号873-73-4 1-氯-4-乙炔基苯 | CAS号99-90-1 4-溴苯乙酮 | CAS号1712-70-5 4-氯-α-甲基苯乙烯 | CAS号64-19-7 冰醋酸 | CAS号108-90-7 氯苯 | CAS号3391-10-4 4-氯苯基-1-乙醇 | CAS号14804-61-6 1-(1-溴乙基)-4-氯苯 | CAS号536-38-9 α-溴代-4-氯苯乙酮 | CAS号57845-08-6 Ethanone,1-(4-c... | CAS号637-87-6 对氯碘苯 | CAS号108664-81-9 2-(4-chlorophen... | CAS号104941-10-8 1-(4-chlorophen... | CAS号10180-02-6 1H-Pyrazole,3-(... | CAS号1078-32-6 Benzoic acid,4-... | CAS号107045-05-6 N-[(E)-1-(4-chl... | CAS号109322-10-3 2-(2-chloroindo... | CAS号10359-12-3 2-(4-chlorophen... | CAS号104941-12-0 1-[2-(4-chlorob... | CAS号104890-73-5 1-(4-chlorophen... | CAS号37592-72-6 4'-己基苯乙酮

4-溴苯乙酮置于nickel Dichloride体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 0.08H,以99%的收率获得产物对氯苯乙酮
参考文献:芳基卤化物中快速简便的卤化物交换
标题:芳基卤化物中快速简便的卤化物交换
摘要:我们在此报告了使用卤化镍 (II) 作为试剂通过微波和常规加热促进芳基卤化物中的快速卤化物交换.该方法可用于将芳基氯化物转化为溴化物,将芳基碘化物转化为溴化物和氯化物以及将芳基溴化物转化为氯化物.反应速度快(微波加热反应时间为 5 分钟,常规加热反应时间为 4 小时),并且无需排除空气和水即可进行.
DOI:10.1055/s-2003-39887

专利信息

专利号:US-10865390-B2
优先权日:2018-02-12
标 题 :Alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols
发明人：NI YE; ZHOU JIEYU; XU GUOCHAO; WANG YUE
权利人:UNIV JIANGNAN
摘要:The present disclosure discloses an alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols, and belongs to the technical field of bioengineering. The alcohol dehydrogenase mutant of the present disclosure has excellent catalytic activity and stereoselectivity, and may efficiently catalyze the preparation of a series of chiral diaryl alcohols in R- and S-configurations. By coupling alcohol dehydrogenase of the present disclosure to glucose dehydrogenase or formate dehydrogenase, the synthesis of chiral diaryl alcohol intermediates of various antihistamines may be achieved. Compared with the prior art, a method for preparing diaryl chiral alcohols through asymmetric catalytic reduction using the alcohol dehydrogenase of the present disclosure has the advantages of simple and convenient operation, high substrate concentration, complete reaction and high product purity, and has great industrial application prospects.

专利号:US-11078465-B2
优先权日:2018-02-12
标题:Alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols
发明人：NI YE; WANG YUE; DAI WEI; XU GUOCHAO; ZHOU JIEYU
权利人:UNIV JIANGNAN
摘要:The present disclosure discloses an alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols, and belongs to the technical field of bioengineering. The alcohol dehydrogenase mutant of the present disclosure has excellent catalytic activity and stereoselectivity, and may efficiently catalyze the preparation of a series of chiral diaryl alcohols in R- and S-configurations. By coupling alcohol dehydrogenase of the present disclosure to glucose dehydrogenase or formate dehydrogenase, the synthesis of chiral diaryl alcohol intermediates of various antihistamines may be achieved. Compared with the prior art, a method for preparing diaryl chiral alcohols through asymmetric catalytic reduction using the alcohol dehydrogenase of the present disclosure has the advantages of simple and convenient operation, high substrate concentration, complete reaction and high product purity, and has great industrial application prospects.

专利号:US-9809522-B2
优先权日:2015-09-11
标 题 :Selective liquefaction of lignin and biomass in a mixture of sub- and supercritical fluids in absence or presence of heterogeneous catalysts
发明人：SMIRNOVA ALEVTINA; LYNDE CHRIS; Numan-Al-Mobin Abu Md; RAJAPPAGOWDA RUDRESH BOMMADIHALLI
权利人:SOUTH DAKOTA BOARD OF REGENTS
摘要:Disclosed herein are methods for selective synthesis of specific phenolic products by means biomass or biomass products liquefaction, manipulation of the said selectivity in favor of one specific phenolic compound or a mixture of specific phenolic compounds, and the synthesis of the phenolic compounds from a liquid or biomass organic fraction produced in presence of a homogeneous catalyst in supercritical state or a mixture of said homogeneous and one or several heterogeneous catalysts mixed with water in sub-critical, near-critical, or supercritical condition.

专利号:US-4871873-A
优先权日:1988-03-18
标 题:Process for synthesis of arylglyoxal arylimines
发明人：DESMOND RICHARD; MILLS SANDER G; VOLANTE RALPH P; SHINKAI ICHIRO
权利人:MERCK & CO INC
摘要:A process for producing arylglyoxal arylimine intermediates, by the DMSO/HBr oxidation of arylmethylketones. The imine compounds are intermediates in the synthesis of carbapenem antibiotics, i.e. imipenem.

专利号:US-3772366-A
优先权日:1964-09-29
标 题 :Process for the preparation of 9beta,10beta steroids
发明人：USKOKOVIC M; WILLIAMS T
权利人:HOFFMANN LA ROCHE
摘要:THE PRESENT INVENTION IS DIRECTED TO A PROCESS FOR THE COMPLETE CHEMICAL SYNTHESIS OF STEROIDS HAVING THE 9B, 10A-CONFIGURATION FROM THE NATURAL STERIOIDS POSSESSING THE 9A, 10B-CONFIGURATION INCLUDING INTERMEDIATES IN THIS SYNTHESIS. THE STEROIDS WITH THE 9B,10A-CONFIGURATION ARE USEFUL AS ANABOLIC AGENTS, ANTI-ANDROGENIC AGENTS, PROGESTATIONAL AGENTS AND AS SALT-RETAINING AGENTS.

专利号:US-6316675-B1
优先权日:1997-03-25
标 题:Process for the preparation of an olefin-substituted aromatic or heteroaromatic compound
发明人：REETZ MANFRED T; LOHMER GUNTHER; LOHMER RENATE
权利人:STUDIENGESELLSCHAFT KOHLE MBH
摘要:A process for the synthesis of olefins having aromatic substituents is described in which olefins are reacted with aryl halides in the presence of catalysts consisting of palladium compounds and tetraaryl phosphonium salts.