📜2,5-二氯苯酚置于sodium Hydroxide,氯,溶剂黄146体系中,化学反应生成 2,4,5-涕丙酸 参考文献:Huisman; Smit,Recueil Des Travaux Chimiques Des Pays-Bas,1955,Vol. 74,P. 155,159 标题:Huisman; Smit,Recueil Des Travaux Chimiques Des Pays-Bas,1955,Vol. 74,P. 155,159
专利号:US-6699981-B2 优先权日:1999-09-22 标题 :Method and compositions for improved polynucleotide synthesis 发明人:YANG SHUWEI 权利人:GENECOPOEIA INC 摘要:The sensitivity and specificity of polynucleotide synthesis is increased by protecting the 3'-end of an oligonucleotide used as a primer in the synthesis of the polynucleotide. Protection of the 3'-end of an oligonucleotide prevents non-specific chain elongation. Removal of blocking group an elevated temperature, using a thermostable enzyme, permits template-specific polynucleotide synthesis. The present invention also provides oligonucleotides with a 3' end protected by a blocking group and a thermostable enzyme capable of removing the blocking group at an elevated temperature. The compositions and methods of the invention are very useful in a variety of techniques for DNA/RNA amplification and analysis, including medical genetics research and diagnosis, pathogen detection, forensic, and animal and plant genetics applications, among others.
专利号:US-8557979-B2 优先权日:2004-06-10 标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation 发明人:CHOI WOO-BAEG; KOWALIK EWA 权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC 摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.
专利号:US-10933051-B2 优先权日:2017-06-09 标 题 :Carbapenem compounds and compositions for the treatment of bacterial infections 发明人:CHOI WOO-BAEG; TOMIOKA TAKASHI; JOO HYUNG-YEUL; TRUONG PHONG; MIN BRIAN 权利人:FOB SYNTHESIS INC 摘要:The present invention provides carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections, including drug resistant or multiple-drug resistant bacterial infections, and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.
专利号:WO-2024256370-A1 优先权日:2023-06-13 标 题 :Synthesis of glufosinate using an amidase-based process 发明人:ZIMMERMANN GUNTHER; POTT MORITZ STEFAN 权利人:BASF SE 摘要:The present invention relates to a method of preparing glufosinate, comprising the steps of hydrolysing an N-carbamoyl glufosinate amide with an Amidase enzyme to form an N- carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N- carbamoyl amino acid compound.
专利号:US-2025120400-A1 优先权日:2021-12-10 标题:Synthesis of glufosinate using a hydantoinase-based process 发明人:DITRICH KLAUS; BREUER MICHAEL; POTT MORITZ STEFAN; ZIMMERMANN GUNTHER; SEEMAYER STEFAN 权利人:BASF SE 摘要:The present invention relates to a method of manufacturing glufosinate, comprising the steps of hydrolysing a hydantoin with a Hydantoinase enzyme to form a N-carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N-carbamoyl amino acid compound.
专利号:US-8782591-B1 优先权日:2012-12-31 标题:Physically aware logic synthesis of integrated circuit designs 发明人:KU TSUWEI; SEIBERT DAVID; WANG HUEY-YIH; SONG HUA; ZHU KAI; CHUNG YU-FANG; SOOD ANKUSH 权利人:CADENCE DESIGN SYSTEMS INC 摘要:In one embodiment of the invention, a method of synthesizing physical gates from register transfer logic code for an integrated circuit design is disclosed. The method includes reading a register transfer level (RTL) input file describing an integrated circuit design; parsing and translating the RTL input file into a plurality of Boolean logic equations; translating the plurality of Boolean logic equations into a plurality of logic primitives; placing the plurality of logic primitives into a floorplan of the integrated circuit design, wherein the placement of the plurality of logic primitives defines wire interconnects; and optimizing each of the plurality of Boolean logic equations in response to wire costs and wire timing delays.