CAS: 89980-69-8; 3,4-Dimethoxyphenylmagnesium Bromide

该化合物是一种Grignard试剂,含有3,4-二甲基氧基混合物组,组装在镁中心;这种有机金属化合物主要用于合成有机化学,用于碳基化合物的核生殖添加,从而形成碳-碳联系;其主要优势包括高反动性与电生物,有利于合成替代芳香衍生物和乙氧循环等复杂分子;存在甲氧基化合物组,增强了其在某些反应中的稳定性和选择性;在无水条件下,它通常用于制备制药,农用化学品和精细化学品;在惰性大气下进行适当处理对于保持其再活性并防止降解至关重要.

结构式图片

上下游产品

4-Bromoveratrole 3,4-dimethoxyphenylacetone 3-(3,4-Dimethoxyphenyl)pyridine 2-(3,4-Dimethoxy-phenyl)-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester 1,2-dimethoxybenzene

合成工艺路线路线简述

  • 2859-78-1 = 89980-69-8
    反应条件:1.1 Reagents: Magnesium,Lithium Chloride Solvents: 1,2-Dibromoethane,Tetrahydrofuran; 1 H,23 °C; 1 H,23 °C
    标题:Ni-Catalyzed Synthesis Of Thiocarboxylic Acid Derivatives
    作者:Monteith,John J.; Scotchburn,Katerina; Mills,L. Reginald; Rousseaux,Sophie A. L.
    参考文献:Organic Letters 日期:2022 卷标:24(2) 页码:619-624]

    2859-78-1 = 89980-69-8
    反应条件:1.1 Reagents: 1,2-Dibromoethane,Magnesium,Lithium Chloride Solvents: Tetrahydrofuran; Cooled; 2 H,Rt
    标题:Ni-Catalyzed C(Sp3)-O Arylation Of α-Hydroxy Esters
    作者:Monteith,John J.; Rousseaux,Sophie A. L.
    参考文献:Organic Letters 日期:2021 卷标:23(24) 页码:9485-9489]

    2859-78-1 = 89980-69-8
    反应条件:1.1 Reagents: Magnesium Catalysts: Iodine Solvents: Tetrahydrofuran; Rt; Rt -> 46 °C1.2 Solvents: Tetrahydrofuran; 46 °C; 30 Min,Reflux
    标题:A Total Synthesis Of (+)-Brazilin
    作者:Huang,Shuangping; Ou,Wentao; Li,Wang; Xiao,Hesheng; Pang,Yiying; Et Al
    参考文献:Tetrahedron Letters 日期:2020 卷标:61(26)]

    2859-78-1 = 89980-69-8
    反应条件:1.1 Reagents: Diisobutylaluminum Hydride,Magnesium,Lithium Chloride Solvents: Toluene,Tetrahydrofuran; 10 Min1.2 Solvents: Tetrahydrofuran; 1 H; 0 °C
    标题:Synthesis Of C-Analogues Of β-Glucogallin And Aldose Reductase Inhibition Studies
    作者:Reddy,Mannem Rajeswara; Aidhen,Indrapal Singh; Shruthi,Karnam; Reddy,Geereddy Bhanuprakash
    参考文献:European Journal Of Organic Chemistry 日期:2017 卷标:2017(48) 页码:7283-7294]

    2859-78-1 = 89980-69-8
    反应条件:1.1 Reagents: Magnesium Catalysts: Iodine Solvents: Tetrahydrofuran; Reflux
    标题:Ring Substitution Influences Oxidative Cyclisation And Reactive Metabolite Formation Of Nordihydroguaiaretic Acid Analogues
    作者:Asiamah,Isaac; Hodgson,Heather L.; Maloney,Katherine; Allen,Kevin J. H.; Krol,Ed S.
    参考文献:Bioorganic & Medicinal Chemistry 日期:2015 卷标:23(21) 页码:7007-7014]

    2859-78-1 = 89980-69-8
    反应条件:1.1 Reagents: Magnesium Catalysts: Iodine Solvents: Tetrahydrofuran; Reflux; 0.5 H,50 °C
    标题:Discovery Of Benzhydrol-Oxaborole Derivatives As Streptococcus Pneumoniae Leucyl-Trna Synthetase Inhibitors
    作者:Hao,Guiyun; Li,Hao; Yang,Fei; Dong,Duoling; Li,Zezhong; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2021 卷标:29]

    2859-78-1 = 89980-69-8
    反应条件:1.1 Reagents: Magnesium,Lithium Chloride Catalysts: 1,2-Dibromoethane Solvents: Tetrahydrofuran; 1 H,23 °C; 1 H,23 °C
    标题:The Cyclopropane Ring As A Reporter Of Radical Leaving-Group Reactivity For Ni-Catalyzed C(Sp3)-O Arylation
    作者:Mills,L. Reginald; Monteith,John J.; Dos Passos Gomes,Gabriel; Aspuru-Guzik,Alan; Rousseaux,Sophie A. L.
    参考文献:Journal Of The American Chemical Society 日期:2020 卷标:142(30) 页码:13246-13254]

    2859-78-1 = 89980-69-8
    反应条件:1.1 Reagents: Magnesium,Iodine; 5 Min,Heated1.2 Solvents: Tetrahydrofuran; Rt
    标题:Facile Formation Of 5-Acylated-2-Hydroxymethyl-Furans From Open Chain D-Glucosyl-Alkyl/aryl Ketones
    作者:Borkar,Santosh R.; Aidhen,Indrapal Singh
    参考文献:Chemistryselect 日期:2016 卷标:1(18) 页码:6004-6007]

    2859-78-1 = 89980-69-8
    反应条件:1.1 Reagents: Magnesium Solvents: Tetrahydrofuran; 45 Min,Rt1.2 Reagents: Iodine; Rt; Rt -> Reflux; 12 H,Reflux
    标题:Dual Inhibitors Of Phosphodiesterase-4 And Serotonin Reuptake
    作者:Cashman,John R.; Voelker,Troy; Zhang,Han-Ting; O'Donnell,James M.
    参考文献:Journal Of Medicinal Chemistry 日期:2009 卷标:52(6) 页码:1530-1539]

    2859-78-1 = 89980-69-8
    反应条件:1.1 Solvents: Diethyl Ether
    标题:Anomalous Acetoxylation Of Aromatic Nuclei: Some Structural Requirements In The Substrate
    作者:Bandaranayake,Wickramasinghe M.; Riggs,Noel V.
    参考文献:Australian Journal Of Chemistry 日期:1981 卷标:34(1) 页码:115-29

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