CAS: 69388-79-0; (2S,5R)-(Pivaloyloxy)Methyl 3,3-Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylate 4,4-Dioxide

上下游产品

Chloromethyl pivalate sodium sulbactam (pivaloyloxy)methyl 6,6-dibromopenicillanate S,S-dioxide tri-n-butyl-tin hydride

(Pivaloyloxy)Methyl 6,6-Dibromopenicillanate S,S-Dioxide置于钯 碳酸氢钠体系中,用 甲醇,水,乙酸乙酯 作为反应溶剂,化学反应生成 舒巴坦匹酯
参考文献:6,6-Dihalopenicillanic Acid 1,1-Dioxides And Process
标题:6,6-Dihalopenicillanic Acid 1,1-Dioxides And Process
摘要:一种制备在体内容易水解的青霉酸1,1-二氧化物及其酯的工艺,包括将6,6-二卤青霉酸或在体内容易水解的其酯氧化为相应的6,6-二卤青霉酸1,1-二氧化物或其酯,然后进行去卤化(例如,通过氢解).在体内容易水解的6,6-二卤青霉酸1,1-二氧化物及其酯是新颖的中间体.青霉酸1,1-二氧化物及其在体内容易水解的酯是已知的化合物,可用作β-内酰胺酶抑制剂,并可增强某些β-内酰胺类抗生素(例如青霉素)在治疗哺乳动物,尤其是人类的细菌感染中的有效性.

专利信息

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.