专利号:US-9920084-B2 优先权日:2011-08-23 标题 :Ionic tags for synthesis of oligoribonucleotides 发明人:DAMHA MASAD J; HASSLER MATTHEW; CHAN TAK-HANG; NANDYALA MALLIKARJUNA REDDY; DONGA ROBERT ALEXANDER 权利人:DAMHA MASAD J; HASSLER MATTHEW; CHAN TAK HANG; NANDYALA MALLIKARJUNA REDDY; DONGA ROBERT ALEXANDER; THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIV; HONG KONG POLYTECHNIC UNIV 摘要:The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II) processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.
专利号:US-2014255328-A1 优先权日:2013-03-11 标 题:Hydrothermal Synthesis of Zinc Phlogopite 发明人:MCGUIRE MEAGHAN CLARK; BULL IVOR; JOHNSON GEOFFREY MARK 权利人:BASF SE 摘要:This invention relates to a synthetically derived zinc phlogopite platelets, of superior platelet diameter, effect pigments comprising such synthetically derived platelets and methods of forming said substrates. More specifically the disclosure describes an improved hydrothermal synthesis of zinc phlogopite suitable as a platelets for interference pigments, barrier and flame retardant applications.
专利号:WO-9611194-A1 优先权日:1994-10-06 标题:Pyridonecarboxylic acid derivative and intermediate for the synthesis of the same 发明人:OKADA HIDETSUGU; CHIBA KATSUMI; TOMINAGA YUKIO; MINAMI AKIRA 权利人:DAINIPPON PHARMACEUTICAL CO; OKADA HIDETSUGU; CHIBA KATSUMI; TOMINAGA YUKIO; MINAMI AKIRA 摘要:A pyridonecarboxylic acid derivative represented by general formula (I), an ester and a salt thereof, an antibacterial agent containing the same, and a bicyclic amine compound serving as a direct intermediate for the synthesis of the pyridonecarboxylic acid derivative, wherein R represents cycloalkyl, optionally substituted phenyl, etc.; G represents carbon, etc.; A represents C-Z (Z being hydrogen, halogeno, lower alkoxy, etc.) or nitrogen; X represents hydrogen, amino, etc.; Y represents hydrogen or halogeno; m is an integer of 1 to 3; and W represents -(CH2)nN(R1)R2 (R1 and R2 being the same or different and each representing hydrogen, lower alkyl, etc., and n being an integer of 0 or 1).
专利号:US-9597327-B2 优先权日:2005-05-25 标 题:Synthesis of (R)-N-methylnaltrexone 发明人:DOSHAN HAROLD D; PEREZ JULIO 权利人:PROGENICS PHARM INC 摘要:This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.
专利号:US-9757317-B2 优先权日:2014-09-12 标题 :Cosmetic compositions and methods for inhibiting melanin synthesis 发明人:LAUGHLIN II LEO TIMOTHY; HAKOZAKI TOMOHIRO; GUPTA SHIKHAR 权利人:PROCTER & GAMBLE 摘要:A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include bisabolol, undecylenoyl phenylalanine and/or hexyldecanol, and a material selected from the group consisting of ethyl palmitate, stearyl alcohol, bis (2-ethylhexyl) adipate, bis (2-ethylhexyl) maleate, 5-pentadecanol, 1-stearoyl-rac-glycerol, bis (2-ethylhexyl) sebacate, and mixtures thereof. A method of reducing the synthesis of melanin by using the cosmetic compositions is also disclosed herein.
专利号:EP-3560934-A1 优先权日:2018-04-26 标题:Process for the preparation of pure 2-cyanophenylboronic acid and esters thereof, intermediates of perampanel or of e2040 发明人:FONTANA FRANCESCO; DI PIETRO FEDERICO; NALIN ARNALDO 权利人:FIS FABBRICA ITALIANA SINTETICI SPA 摘要:The present invention relates to a process for the synthesis of 2-cyanophenylboronic acid and the esters and salts thereof, which are intermediates of the synthesis of active pharmaceutical ingredients such as Perampanel or E2040, wherein impurity formation, in particular the formation of DBBN iPrketone, is reduced.
摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118 摘要:International Journal of Toxicology 25(Suppl. 2) :1-89,2006 摘要:International Journal of Toxicology 31(Suppl 1):5-76, 2012 摘要:International Journal of Toxicology 24(Suppl. 1):1-102, 2005 摘要:Journal of the American College of Toxicology 3(3):101-130, 1984