专利号:WO-9104337-A1 优先权日:1989-09-25 标题 :ENANTIOSELECTIVE, ENZYMATIC SYNTHESIS OF S(-) and R(+) ESTERS OF 4-HYDROXY-CYCLOPENTENE-1-ONE AND ITS 2',2'-DIMETHYLPROPANE-1',3'-DIOL-KETAL 发明人:SCHAPOEHLER STEFAN B; SCHEPER THOMAS; SCHUEGERL KARL 权利人:EUROP COMMUNITIES 摘要:The S(-) and R(+) esters of 4-hydroxy-cyclopentene-1-one and its 2',2'-dimethylpropane 1',3'-diol-ketal are produced by direct, enantioselective, enzymatic synthesis by reacting the corresponding 4-hydroxy compounds with an ester as acyl donor in the presence of an enzyme. The esters obtained are valuable intermediate products for stereospecific synthesis, in particular for the stereoselective synthesis of chemical compounds, in particular stable, storable, chiral prostaglandin derivatives, especially storable chiral prostaglandinsynthone.
专利号:US-9267090-B2 优先权日:2009-07-07 标 题:Synthesis of biolubricant esters from unsaturated fatty acid derivatives 发明人:ELOMARI SALEH ALI; MILLER STEPHEN JOSEPH; ZHOU ZHEN 权利人:ELOMARI SALEH ALI; MILLER STEPHEN JOSEPH; ZHOU ZHEN; CHEVRON USA INC 摘要:The present invention is generally directed to diester-based lubricant compositions comprising one or more isomeric mixtures of diester species. The present invention is also directed to methods of making these and other similar lubricant compositions. In some embodiments, the methods for making such diester-based lubricants utilize a biomass precursor material from which mono-unsaturated free lipid species can be provided or otherwise generated, wherein such mono-unsaturated free lipid species are converted to isomeric diol species en route to the synthesis of diester species for use as/in the diester-based lubricant compositions.
专利号:WO-2021137711-A1 优先权日:2019-12-31 标题 :Synthesis of polyesters in aqueous polymerization systems 'from solid to solid' via biocatalysis 发明人:JOAQUIM PINA DA FONSECA LUIS; CAROLINA DOLVITSCH PFLUCK ANA; POPOVIC CORREIA DE BARROS DRAGANA 权利人:INST SUPERIOR TECNICO 摘要:The present invention relates to a process for the synthesis of polyesters comprising reacting a dicarboxylic acid monomer with a dialcohol monomer, in an equimolar concentration in the range of 0.2 M to 1.0 M, in the presence of a biocatalyst, in an aqueous polymerization medium, at a temperature in the range of 25-45°C, the biocatalyst being in the form of an enzyme immobilized on a solid support. The present invention further provides a copolymer obtained by the invention process.
专利号:US-5776741-A 优先权日:1994-02-21 标题:Method of enzyme immobilization on a particulate silica carrier for synthesis inorganic media 发明人:PEDERSEN SVEN; LARSEN ANNE MORKEBERG; AASMUL PER 权利人:NOVO NORDISK AS 摘要:An immobilized enzyme is prepared for synthesis in a mainly organic medium devoid of free water. In one embodiment, an enzyme and liquid binder are introduced by atomization onto a particulate silica carrier having a particle size below 100 μm in a granulator and simultaneously granulating to form the immobilized enzyme. In another embodiment, a liquid enzyme composition is contacted with the particulate silica carrier to obtain a particulate immobilized enzyme having a particle size below 100 μm, the immobilized enzyme is introduced into granulator, a liquid binder is introduced into the granulator and granulation is carried out. The enzyme is preferably a lipase such as a thermostable lipase, and the immobilized lipase is used for interesterification of fats or synthesis of fatty acid esters.
专利号:EP-0542969-B1 优先权日:1991-06-04 标 题:Biodegradable particulate vector and method of synthesis 发明人:SAMAIN DANIEL; DE MIGUEL IGNACIO; MENIALI JAOUAD; IOUALALEN KARIM; DING LI; CERVILLA MONIQUE; RIEUMAJOU VALERIE; DELRIEU PASCAL; IMBERTIE LAURENT 权利人:BIOVECTOR THERAPEUTICS SA 摘要:A biodegradable particulate vector is disclosed and is characterized in that it comprises: a nucleus consisting of a cross-linked polysaccharide or oligosaccharide matrix to which ionic ligands are attached; a first semi-permeable lipid layer linked to the nucleus by covalent bonds; a second layer of amphiphilic compounds linked to the first lipid layer by hydrophobic interactions. A method for synthesis of said vector is also disclosed.
专利号:US-6869973-B2 优先权日:2000-06-22 标题:Nitrosated and nitrosylated taxanes, compositions and methods of use 发明人:GARVEY DAVID S; LETTS L GORDON; LIN CHIA-EN; RICHARDSON STEWART K; WANG TIANSHENG 权利人:NITROMED INC 摘要:The present invention describes novel nitrosated and/or nitrosylated taxanes, and novel compositions comprising at least one nitrosated and/or nitrosylated taxane, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The present invention also provides novel compositions comprising at least one taxane and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The compounds and compositions of the present invention can also be bound to a matrix. The present invention also provides methods for treating or preventing cardiovascular diseases and disorders, autoimmune diseases, pathological conditions resulting from abnormal cell proliferation, polycystic kidney disease, inflammatory disease, preserving organs and/or tissues or to inhibit wound contraction, particularly the prophylactic and/or therapeutic treatment of restenosis, by administering nitrosated and/or nitrosylated taxane or parent taxanes in combination with nitric oxide donors that are capable of releasing nitric oxide or indirectly delivering or transferring nitric oxide to targeted sites under physiological conditions.
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