专利号:US-7956011-B2 优先权日:2005-05-04 标题:Materials and methods for the photodirected synthesis of oligonucleotide arrays 发明人:SERAFINOWSKI PAWEL JERZY; GARLAND PETER BRYAN 权利人:CANCER RES INST ROYAL 摘要:Materials and methods for photodirected synthesis of oligonucleotide arrays on a solid substrate by photodirected synthesis are disclosed which employ a film formed from (i) a photoacid generator that on photolysis generates acid that is capable of directly removing the protecting group of the linker molecules or oligonucleotides and (ii) a polymer substantially lacking electronegative heteroatoms that are capable of hydrogen bonding with photogenerated acid. Methods of synthesizing an oligomer arrays are also described that use a film that restricts diffusion of reactants and products on the substrate during synthesis of the array and which includes a precursor of a deprotecting reagent. The method involves removing one or more of the non-required products of the deprotection reaction from the reactive array elements at which they are produced during the reaction, in order to displace the deprotection reaction towards completion.
专利号:WO-2023112055-A1 优先权日:2021-12-15 标 题 :New synthetic process design for the synthesis of carboxy tormifene and purity analysis to strengthen antidoping testing 发明人:KUMAR GANGASANI JAGADEESH; PAWAR SACHIN DATTRAM; RADHAKRISHNANAND PULLAPANTHULA; MURTY UPADHYAYULA SURYANARAYANA; SAHU PURAN LAL; DUBEY SACHIN; SAHU KAPENDRA; UPADHYAY AWANISH; KUMAR PRAMOD 权利人:DIRECTOR NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RES GUWAHATI NIPER G; DIRECTOR NAT DOPE TESTING LABORATORY NDTL 摘要:The present invention relates to a process for preparing a compound of formula I: I. The compound of formula I is useful in anti-doping tests.
专利号:US-10941243-B2 优先权日:2016-10-13 标 题 :Polymer poly (triphenylacrylonitrite) and synthesis thereof 发明人:TANG BENZHONG; QIU ZIJIE 权利人:UNIV HONG KONG SCI & TECH 摘要:A method is directed to synthesis of poly(triphenylacrylonitrite)s (PTPANs) comprising polycoupling dibromoarenes, internal diynes, and potassium ferrocyanide, resulting in polycoupled dibromoarenes, internal diynes, and potassium ferrocyanide; and producing poly(triphenylacrylonitrite)s (PTPANs) by catalysis of the polycoupled dibromoarenes, internal diynes, and potassium ferrocyanide with palladium acetate and sodium bicarbonate, wherein the catalysis is allowed to proceed in dimethylacetamide under nitrogen at a prescribed temperature for a prescribed time. Further, poly(triphenylacrylonitrite)s (PTPANs) is a polymer and comprises a backbone structure of n nwherein x and y are integers;n nwherein each R is independently selected from the group consisting ofn n nandn nwherein each R′ is independently selected from the group consisting of
专利号:US-5783577-A 优先权日:1995-09-15 标题 :Synthesis of quinazolinone libraries and derivatives thereof 发明人:HOUGHTEN RICHARD A; OSTRESH JOHN M 权利人:TREGA BIOSCIENCES INC 摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.
专利号:US-6538128-B1 优先权日:1997-09-08 标题:Detritylation solvents for nucleic acid synthesis 发明人:ZHANG GUANGRONG; TANG JIN-YAN 权利人:AVECIA BIOTECHNOLOGY INC 摘要:The invention provides improved processes for oligonucleotide synthesis utilizing arenes as solvents for detritylation of oligonucleotides.
专利号:US-7582653-B2 优先权日:2003-03-31 标 题 :Mercaptophenyl naphthyl methane compounds and synthesis thereof 权利人:COUNCIL SCIENT IND RES 摘要:Novel mercaptophenyl naphthyl methane compounds, their pharmaceutically acceptable salts and compositions comprised thereof are useful for the prevention or treatment of various medical indications associated with estrogen dependent diseases or syndromes related to osteoporosis, bone loss, bone formation, cardiovascular disorders, neurodegenerative disorders, menopausal disorders, physiological disorders, diabetes disorders, prostatic carcinoma, cancer of breast, cancer of uterus, cancer of the cervix and cancer of the colon, threatened or habitual abortion, obesity, ovarian development or function, post-partum lactation and depression.
1: Abderrahman B, Maximov PY, Curpan RF, Fanning SW, Hanspal JS, Fan P, Foulds CE, Chen Y, Malovannaya A, Jain A, Xiong R, Greene GL, Tonetti DA, Thatcher GRJ, Jordan VC. Rapid Induction of the Unfolded Protein Response and Apoptosis by Estrogen Mimic TTC-352 for the Treatment of Endocrine-Resistant Breast Cancer. Mol Cancer Ther. 2021 Jan;20(1):11-25. doi: 10.1158/1535-7163.MCT-20-0563. Epub 2020 Nov 11. 2: Rani S, Paul K. Triphenylethylene analogues: Design, synthesis and evaluation of antitumor activity and topoisomerase inhibitors. Eur J Med Chem. 2020 Dec 15;208:112775. doi: 10.1016/j.ejmech.2020.112775. Epub 2020 Aug 30. 98(4):364-381. doi: 10.1124/molpharm.120.000054. Epub 2020 Aug 12. Erratum in: Mol Pharmacol. 2020 Oct;98(4):528. 4: Maximov PY, Abderrahman B, Hawsawi YM, Chen Y, Foulds CE, Jain A, Malovannaya A, Fan P, Curpan RF, Han R, Fanning SW, Broom BM, Quintana Rincon DM, Greenland JA, Greene GL, Jordan VC. The Structure-Function Relationship of Angular Estrogens and Estrogen Receptor Alpha to Initiate Estrogen-Induced Apoptosis in Breast Cancer Cells. Mol Pharmacol. 2020 Jul;98(1):24-37. doi: 10.1124/mol.120.119776. Epub 2020 May 3.
合成参考文献
摘要:Zaidlewicz, M.; Krzemiński, M. P.; Dzieleńdziak, A., Science of Synthesis, (2009) 48, 382. 摘要:Wang, K.; Wang, J., Science of Synthesis, (2022) , 11. 摘要:Matsumoto, K.; Katsuki, T.; Arends, I. W. C. E., Science of Synthesis: Stereoselective Synthesis, (2011) 1, 105. 摘要:Matsumoto, K.; Katsuki, T.; Arends, I. W. C. E., Science of Synthesis: Stereoselective Synthesis, (2011) 1, 104. 摘要:Wong, O. A.; Ramirez, T. A.; Shi, Y., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 820.