CAS: 5446-02-6; Methyl 2-Hydroxy-4-Methoxybenzoate

上下游产品

CAS号67-56-1 甲醇 | CAS号2237-36-7 4-甲氧基水杨酸 | CAS号89-86-1 2,4-二羟基苯甲酸 | CAS号74-88-4 碘甲烷 | CAS号2150-41-6 2,4-二甲氧基苯甲酸甲酯 | CAS号77-78-1 硫酸二甲酯 | CAS号1092940-55-0 methyl 2-(metho... | CAS号186581-53-3 重氮甲烷 | CAS号39835-11-5 2-羟基-4-甲氧基苯甲腈 | CAS号50343-02-7 3-溴-2-羟基-5-甲氧基苯甲醛 | CAS号41697-08-9 2-羟基-4-甲氧基苯碳酰肼 | CAS号2555-24-0 4-羟基-7-甲氧基-3-苯基香豆素 | CAS号6745-77-3 4-甲氧基水杨酰胺 | CAS号31456-95-8 Methyl 2-(allyl... | CAS号33562-12-8 methyl 4-methox... | CAS号13618-49-0 2-(Benzyloxy)-4... | CAS号16292-95-8 3-甲氧基-4-硝基苯酚 | CAS号2237-36-7 4-甲氧基水杨酸

2,4-二羟基苯甲酸置于硫酸,Potassium Carbonate体系中,用 丙酮 作为反应溶剂,化学反应 27.0H,反应生成 4-甲氧基水杨酸甲酯
参考文献:Natural Product-Inspired Rational Design,Synthesis And Biological Evaluation Of 2,3-Dihydropyrano[2,3-F]Chromen-4(8 H)-One Based Hybrids As Potential Mitochondrial Apoptosis Inducers
标题:Natural Product-Inspired Rational Design,Synthesis And Biological Evaluation Of 2,3-Dihydropyrano[2,3-F]Chromen-4(8 H)-One Based Hybrids As Potential Mitochondrial Apoptosis Inducers
摘要:Synthesis Of Novel Pyranochromanone Amide Hybrids,By Combining Pyranochromanone Pharmacophore And Privileged Scaffolds Such As 2-Amino-1,3,4-Thiadiaole/2-Aminothiazole/aminopyridine/amino-Naphthalene And Anti-Cancer Evaluation Of A Series Led Us To Discover A Series Of New Chemical Entities (Nces) Showing Broad Spectrum Of Anti-Cancer Activity Against Three Different Human Cancer Cell Lines (Mcf-7,A549 And Hela),At Ic50 Values Ranging From 14.3 To 97.8 Mu M. Among Them,Some Compounds Such As 15B,15D,20A And 20B Displayed Excellent Activity Against Breast Cancer Cell Line Mcf-7. Detailed Biological Studies Such As Ao/eb Dual Staining,Hoechst 33342 Staining,Facs Analysis Of Mitochondrial Membrane Potential (Delta Psi(M)) Using Jc-1 Dye And Dna Fragmentation Confirmed The Apoptosis Induced By The Hybrids. Gene Expression Studies By Real Time Rt-Pcr Has Shown That These Compounds Are Efficient Regulator Of Anti-Apoptotic Gene Bcl-2. Western Blot Analysis Also Revealed That These Compounds Persuade Apoptosis Through Intrinsic Pathway By Up-Regulating The Pro-Apoptotic Protein Bax And Down Regulating The Anti-Apoptotic Protein Bcl-2. Molecular Docking Studies Reveal That Compounds 15B And 20B Binds Efficiently With Bci-2 Promoter G-Quadruplex. (C) 2016 Elsevier Masson Sas. All Rights Reserved.
DOI:10.1016/j.Ejmech.2016.06.044

专利信息

专利号:US-9988368-B1
优先权日:2017-06-16
标题:Chiral synthesis method for producing cis-imidazoline compounds for pharmaceutical use
发明人：VON GELDERN THOMAS W; BACKES BRADLEY; CHEN BING
权利人:UNITY BIOTECHNOLOGY INC
摘要:This invention provides a method for enantioselective synthesis of cis-imidazolines and related structures through chiral resolution. A chiral acid is used to separate enantiomeric precursors of the cis-imidazolines from a racemic mixture by selective crystallization. Both enantiomers can be cyclized into the desired cis-imidazoline by complementary pathways. Compounds can be synthesized according to the invention with an enantiomeric excess as high as 99%. Cis-imidazolines such as Nutlin-3a prepared according to this invention may be used for treating cancer, killing senescent cells, or treating senescence-associated conditions.

专利号:WO-2009011653-A1
优先权日:2007-07-17
标题:A process for the preparation of intermediates and their us in the synthesis of spiropiperidine compounds

专利号:US-2009259055-A1
优先权日:2008-02-29
标题:Catalytic enantioselective synthesis of flavanones and chromanones

专利号:US-2019270726-A1
优先权日:2017-06-16
标题:Products of chiral synthesis of cis-imidazoline compounds and their use

专利号:US-2011117649-A1
优先权日:2008-02-29
标题:Catalytic enantioselective synthesis of flavanones and chromanones

专利号:US-7851640-B2
优先权日:2008-02-29
标 题 :Catalytic enantioselective synthesis of flavanones and chromanones
发明人：SCHEIDT KARL; BIDDLE MARGARET MARIE
权利人:UNIV NORTHWESTERN
摘要:Various chromanone, flavanone and abyssinone compounds as can be prepared enantioselectively using a chiral thiourea catalyst.