CAS: 54143-56-5; N-(Piperidin-2-Ylmethyl)-2,5-Bis(2,2,2-Trifluoroethoxy)Benzamide Acetate

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CAS号57415-36-8 N-(2-吡啶基甲基)-2,5... | CAS号64-19-7 冰醋酸 | CAS号54143-55-4 氟卡尼

📜N-(2-吡啶基甲基)-2,5-二(2,2,2-三氟乙氧基)苯甲酰胺置于pt-C体系中,用 溶剂黄146 作为反应溶剂,以89%的收率获得产物醋酸氟卡尼
参考文献:&agr;,&agr;-Dibromo-&agr;-Chloro-Acetophenones As Synthons
标题:&agr;,&agr;-Dibromo-&agr;-Chloro-Acetophenones As Synthons
摘要:这项披露涉及使用α,α-二溴-α-氯乙酰苯酮化合物作为制备芳香酮化合物的中间体,特别是芳香酰胺.化合物2,5-双(2,2,2-三氟乙氧基)-α,α-二溴-α-氯乙酰苯酮尤其适用于制备已知药物非卡因.

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-7196197-B2
优先权日:2003-09-17
标题:Process for the preparation of Flecainide, its pharmaceutically acceptable salts and important intermediates thereof
发明人：WANG ZHI-XIAN; LI YUANQIANG; GUNTOORI BHASKAR REDDY
权利人:APOTEX PHARMACHEM INC
摘要:Process for the preparation of Flecainide, its pharmaceutically acceptable salts and important intermediates thereof that involves the use of the 2-halobenzoic acid and its derivatives as a starting material. The use of this process also allows for the synthesis of a novel intermediate useful in the production of Flecainide. This new process is an inexpensive and efficient process for the manufacture of these compounds.

专利号:US-6599922-B2
优先权日:2001-08-10
标 题:Process for the preparation of 2,5-bis-(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)-benzamide (FLECAINIDE)
发明人：VIGANO ENRICO; PIZZATTI ENRICA; MOLTENI RENATO; LANFRANCONI SIMONA
权利人:A M S A ANONIMA MATERIE SINT E
摘要:Process for the synthesis of FLECAINIDE comprising the reaction between 2,5-dihydroxybenzoic acid with trifluoroethanol perfluorobutanesulphonate to give the intermediate trifluoroethanol 2,5-bis-trifluoroethoxybenzoate, the reaction of said intermediate with 2-aminomethylpiperidine to give FLECAINIDE.

专利号:US-7825268-B2
优先权日:2003-12-23
标 题:Alkoxylactones, alkoxylactams and alkoxythiolactams for controlling processes based on microbial interaction
发明人：STUMPE STEFAN; BREVES ROLAND; HUCHEL URSULA; JANSSEN FRANK; HAETZELT ANDRE
权利人:HENKEL AG & CO KGAA
摘要:Compounds of the Formula I, n nwherein A 1 is O or NH; A 2 is O or S; each of R 1 and R 2 is independently hydrogen, a methyl or C 2 -C 8 -saturated or mono- or doubly unsaturated, branched or linear hydrocarbon group; and R 3 is a C 1 -C 18 -saturated or mono- or doubly unsaturated, branched or linear hydrocarbon group wherein, each of R 1 , R 2 and R 3 comprises a heteroatom selected from the group consisting of O and S in the chain and/or is mono- or multiply-substituted by a substituent selected from the group consisting of halogen, hydroxy, C 1 -C 6 -alkyl, trifluoromethyl, C 1 -C 6 -alkoxy, C 6 -C 10 -aryl, and C 1 -C 6 -alkyl-C 6 -C 10 -aryl are useful for controlling the interaction process between microorganisms such as in the development and/or maturation of biofilms; multicellular swarm behavior; the concerted development of antibiotic resistances; the concerted synthesis of antibiotics; the concerted synthesis of pigments; the concerted production of extracellular enzymes; or the concerted production of virulence factors.

专利号:US-10814013-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:US-2008107598-A1
优先权日:2006-10-05
标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications