CAS: 52663-62-4; 2,3,4,2',3'-Pentachlorobiphenyl

该化合物是多氯联苯(PCB)家族的成员,该家族由不同程度氯化的合成有机化学品组成.多氯联苯82具有联苯结构特征,含有联苯框架所附的多种氯原子,影响其物理和化学特性,通常无色于浅黄色固体或液体,视其浓度和配方而定.多氯联苯,包括多氯联苯82,因其疏水性,热稳定性和耐降解性而闻名,使其在环境中具有持久性,它们具有亲脂性,导致活生物体生物体的生物累积.多氯联苯82被用于各种工业应用,包括电气设备,热传输液和其他材料中的添加剂.然而,由于其毒性和可能造成不良健康影响,包括内分泌干扰和致癌性,许多国家已禁用或严格管制多氯联苯.环境监测和补救工作正在进行,以解决多氯联苯污染的遗留问题.

英文名称2,3,4,2',3'-Pentachlorobiphenyl
中文名称多氯联苯1254标准品
IUPAC名称1,2,3-trichloro-4-(2,3-dichlorophenyl)benzene
其它别名2,2',3,3',4-Pentachloro-1,1'-biphenyl; 2,2',3,3',4-Pentachlorobiphenyl; 2,2',3,3',4'-Pentachlorobiphenyl; 2,3,2',3',4'-Pentachlorobiphenyl; 2,3,4,2',3'-Pentachlorobiphenyl; PCB 82
CAS编号52663-62-4
MFCD编号:MFCD00152708
分子式:C12H5Cl5分子量:326.43
产品CID: 2498332
产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃

相似结构搜索
产品信息参考;;;;
InChIKey: AUGNBQPSMWGAJE-UHFFFAOYSA-N
1S/C12H5Cl5/c13-8-3-1-2-6(10(8)15)7-4-5-9(14)12(17)11(7)16/h1-5H
计算化学: 氢键受体数*氢键供体数0.0可旋转键数1.0

物理性质

熔点95.86°C (估算)
沸点412.3°C (粗估)
闪点-12 °C
密度1.5220 (粗估)
LogP:6.6206
折射率1.6200 (粗估)
蒸汽压7.71X10-5 mm Hg at 25 °C (avg)
溶解性29.08ug/L(20 °C)
外观形态Light yellow, viscous liquid | Colorless to pale-yellow, viscous liquid or solid (below 50 degrees F)

MSDS等安全信息

警示词Danger
危险描述H302: Harmful if swallowed [Warning Acute toxicity, oral]
H311: Toxic in contact with skin [Danger Acute toxicity, dermal]
H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
H350: May cause cancer [Danger Carcinogenicity]
H360: May damage fertility or the unborn child [Danger Reproductive toxicity]
H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
防范说明P203, P260, P261, P262, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P316, P318, P319, P321, P330, P361+P364, P403+P233, P405, and P501
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)
危险类别码Polychlorinated biphenyls are mixtures of up to 209 individual chlorinated compounds (known as congeners). There are no known natural sources of PCBs. PCBs are either oily liquids or solids that are colorless to light yellow. Some PCBs can exist as a vapor in air. PCBs have no known smell or taste. Many commercial PCB mixtures are known in the U.S. by the trade name Aroclor.PCBs have been used as coolants and lubricants in transformers, capacitors, and other electrical equipment because they don't burn easily and are good insulators. The manufacture of PCBs was stopped in the U.S. in 1977 because of evidence they build up in the environment and can cause harmful health effects. Products made before 1977 that may contain PCBs include old fluorescent lighting fixtures and electrical devices containing PCB capacitors, and old microscope and hydraulic oils. | This is a family of 209 chemicals, usually mixtures, contaminated with furans and dioxins. They persist in the environment and concentrate upward in the food chain. Primary nonoccupational exposure is from food, especially fish from contaminated water (e.g.. Lake Michigan). PCB's evaporate slowly at room temperature but have increased volatility with small increases in temperature, e.g.. overheated equipment. PCBs can induce chloracne in exposed humans. Abnormal liver function tests may be seen after PCB exposure, but this effect has not been documented in PCB-exposed workers. Serum PCB levels are difficult to interpret, and they are not recommended in the clinical evaluation. Neonatal PCB syndrome (low birth weight, hyperpigmentation, eye abnormalities) has been described. PCBs cause fetal loss and low birth weight in experimental animals. [ATSDR Case Studies: PCB Toxicity] A cohort of 7075 capacitor workers, exposed to PCBs in 1946-75 and followed through 1998, has not experienced any excess mortality from cancer or other causes. [PubMed ID: 12661184] The accepted view is that exposure to PBBs or PCBs leads to hepatic injury only when they are sufficiently contaminated with PCDFs. (PCDFs = polychlorinated dibenzofurans.) [Zimmerman, p. 395] See Polychlorinated biphenyls and linked occupational disease.

上下游产品

2,3-dichloroaniline 1,2,3-trichlorobenzene biphenyl

合成工艺路线路线简述

📜2,3-二氯苯胺,三氯苯置于sodium Acetate,亚硝酸体系中,化学反应生成多氯联苯1254标准品
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4