CAS: 4312-32-7; 6,7,12B,13-Tetrahydro-4H-[1,3]Dioxolo[4',5':7,8]Isoquinolino[3,2-A][1,3]Dioxolo[4,5-G]Isoquinoline

上下游产品

rac-7-methyl-2,3;9,10-bis-methylenedioxy-berbinium; chloriderac-7-methyl-2,3;9,10-bis-methylenedioxy-berbinium; chloride H-[1,3]dioxolo[4,5-g][1,3]dioxolo[4',5':7,8]isoquino[3,2-a]isoquinoline14-bromo-6,7,12b,13-tetrahydro-4H-[1,3]dioxolo[4,5-g][1,3]dioxolo[4',5':7,8]isoquino[3,2-a]isoquinoline coptisine chloride 7,8-methylenedioxy-2-(3,4-methylenedioxyphenethyl)-1,2,3,4-tetrahydroisoquinolin-3-one protopine corydamine coptisine chloride

📜N-Methyl-13,14-Dehydrostylopinium Chloride置于sodium Tetrahydroborate体系中,用 甲醇,二甲基亚砜 作为反应溶剂,化学反应 25.5H,反应生成 四氢黄连碱
参考文献:从protopines到berbines:从库特罗平合成1-甲氧基斯蒂氯平及其n-甲基盐
标题:从protopines到berbines:从库特罗平合成1-甲氧基斯蒂氯平及其n-甲基盐
摘要:在改善的条件下将原松树素转化为小bin碱已被用于合成1-甲氧基stylopine.coulteropine,从主要生物碱romneya Coulteri,被用作起始普罗托实现两者的立体控制合成顺式和反式ñ-甲基-1-Methoxystylopinium盐.从头算的结果(b3Lyp / 6-31G ∗∗)与实验数据一致,维持了c-1取代基对小bin素的构象平衡和n-甲基化率的影响.
DOI:10.1016/s0040-4020(02)00467-2

专利信息

专利号:WO-2025031833-A1
优先权日:2023-08-04
标 题:Recombinant strain and use thereof in production of scoulerine
发明人：CHEN YUN; JIAO XIANG
权利人:CHRYSEA LTD; CHEN YUN
摘要:Disclosed are recombinant yeast strains and a use thereof in the production of a benzylisoquinoline alkaloid. The recombinant yeast strains comprise berberine bridge enzyme. De novo synthesis of scoulerine and a benzylisoquinoline alkaloid is achieved through multiple strategies, and the yield thereof is significantly increased. The recombinant yeast strains provided by the present invention can produce scoulerine and other benzylisoquinoline alkaloids at high efficiency, and has important value in applications.

专利号:US-10793885-B2
优先权日:2013-08-16
标 题 :Compositions and methods for making noscapine and synthesis intermediates thereof
发明人：FACCHINI PETER JAMES; CHEN XUE; DANG THI THU THUY
权利人:WILLOW BIOSCIENCES INC
摘要:Methods for the manufacture of the therapeutic chemical compound noscapine and noscapine synthesis intermediates comprising contacting a noscapine pathway precursor selected from a first canadine derivative, a first papaveroxine derivative and narcotine hemiacetal with at least one of the enzymes selected from the group CYP82Y1, CYP82X1, AT1, CYP82X2, OMT, CXE1 and NOS.

专利号:CN-106085981-A
优先权日:2016-06-30
标题 :Methyltransferase gene involved in the synthesis of sanguinarine and chelerythrine in Boluohui and its application

专利号:CN-106119265-A
优先权日:2016-06-30
标题 :Cytochrome P450 enzyme gene involved in the synthesis of sanguinarine and chelerythrine in Boluohui and its application