CAS: 39065-95-7; 4-(Chlorodifluoromethoxy)Aniline

上下游产品

CAS号40750-71-8 1-[chloro(diflu...

1-(氯-二氟-甲氧基)-4-硝基苯置于sodium Tetrahydroborate,Tpgs-750-M体系中,用 四氢呋喃,水 作为反应溶剂,化学反应 0.5H,以91%的收率获得产物4-氯二氟甲氧基苯胺
参考文献:掺有ppm级(pd + Ni)的fe纳米颗粒中的协同效应.可持续还原硝基的新催化剂
标题:掺有ppm级(pd + Ni)的fe纳米颗粒中的协同效应.可持续还原硝基的新催化剂
摘要:在铁纳米颗粒中嵌入的pd和ni的ppm水平之间发现了显着的协同作用,这导致室温下水中的含硝基芳族化合物和杂芳族化合物温和选择性催化还原.nabh 4用作廉价氢化物的来源.记录了广泛的基材范围以及其他一些功能,包括:催化剂用量低,产品中残留金属少,催化剂和反应介质的循环利用,凸显了这项新技术的绿色本质.
DOI:10.1039/c7Gc02991H

专利信息

专利号:US-12240835-B2
优先权日:2018-09-18
标题:Substituted benzamides as intermediates in the synthesis of inhibitors of tyrosine kinase enzymatic activity
发明人：ROMERO F ANTHONY; KIRSCHBERG THORSTEN A; HALCOMB RANDALL; XU YINGZI
权利人:TERNS PHARMACEUTICALS INC
摘要:Provided herein are compounds, preferably compounds inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, compositions thereof, and methods of their preparation, and methods of inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, and methods for treating diseases wherein modulation of BCR-ABL1 activity prevents, inhibits, or ameliorates the pathology and/or symptomology of the disease. Intermediates such as compounds of Formula (S23), which are useful in the synthesis of compounds inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, are also provided.

专利号:US-11236070-B2
优先权日:2019-05-16
标 题 :Chemical process
发明人：BLANK JARRED; KOECHER CHRISTIAN; PACHINGER WERNER HEINZ; PAREDES GALATEA; SPAETI MARKUS
权利人:NOVARTIS AG
摘要:The present invention provides a novel chemical process for the synthesis of the compound N-[4-(Chlorodifluoromethoxy)phenyl]-6-[(3R)-3-hydroxpyrrolidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide.