CAS: 38136-29-7; 4-Methylvaleryl Chloride

上下游产品

CAS号646-07-1 4-甲基戊酸 | CAS号79-37-8 草酰氯 | CAS号10321-71-8 4-甲基-2-戊烯酸 | CAS号7719-09-7 氧氯化硫 | CAS号1119-29-5 Pentanamide, 4-... | CAS号108-94-1 环己酮 | CAS号2050-07-9 1-Pentanone,4-m... | CAS号3016-28-2 Hexanamide, 5-methyl | CAS号2508-63-6 DL-Leucine, hyd... | CAS号2808-27-7 Pentanoic acid,... | CAS号2999-14-6 4-methyl-1-(2,4... | CAS号328-38-1 D-亮氨酸 | CAS号646-07-1 4-甲基戊酸 | CAS号2050-99-9 2,8-二甲基-5-壬酮

4-甲基戊酸置于草酰氯体系中,用 二氯甲烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 2.0H,反应生成异己酰氯
参考文献:未活化 C-H 键的光诱导远程区域选择性自由基炔基化
标题:未活化 C-H 键的光诱导远程区域选择性自由基炔基化
摘要:已经开发了一种通过光生酰胺基自由基对不同脂肪族酰胺中未活化的 C(Sp 3 )-H 键进行远程区域选择性炔基化的方法.位点选择性主要通过酰胺的 1,5-氢原子转移 (Hat) 过程.该方法证明了温和的反应条件和高区域选择性.
Doi:10.1039/d1Cc06885G

专利信息

专利号:US-6849743-B2
优先权日:1997-08-15
标 题 :Synthesis of clasto-lactacystin β-lactone and analogs thereof
发明人：SOUCY FRANCOIS; FLAMONDON LOUIS; BEHNKE MARK; ROUSH WILLIAM
权利人:MILLENNIUM PHARM INC
摘要:The present invention is directed to an improved synthesis of clasto-lactacystin-β-lactone, and analogs thereof, that proceeds in fewer steps and in much greater overall yield than syntheses described in the prior art. The synthetic pathway relies upon a novel stereospecific synthesis of an oxazoline intermediate and a unique stereoselective addition of a formyl amide to the oxazoline. Also described are novel clasto-lactacystin-β-lactones, and analogs thereof and their use as proteasome inhibitors.

专利号:US-7183059-B2
优先权日:1998-03-23
标 题 :Synthesis of compounds and libraries of compounds
发明人：VERDINE GREGORY L; CHYTIL MILAN; DIDIUK MARY T; MALINKY TIFFANY
权利人:HARVARD COLLEGE
摘要:A method of generating a compound having at least one biological activity of a peptide. The method includes identifying a biologically active peptide, providing a first monomer which contains terminal reactive moieties and at least one functionalizable group, providing a second monomer which contains terminal reactive moieties and at least one functionalizable group, and reacting first and second monomer under stereo-and/or regiochemically controlled conditions to yield a compound in which the monomers are attached by way of terminal reactive moieties.

专利号:US-5256811-A
优先权日:1991-05-23
标 题:Certain intermediates for the preparation of neuinic acid derivatives
发明人：TODD RICHARD S; REEVE MAXWELL
权利人:BRITISH BIO TECHNOLOGY
摘要:compounds of formula I ##STR1## wherein R 1 represents a C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl(C 1-8 )alkyl, C 1-8 hydroxyalkyl, C 1-8 alkylthio, phenyl or substituted phenyl; n R 3 represents a C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, CO2(C 1-8 )alkyl, CO 2 (C 2-8 ) alkenyl, C 1-8 alkylthio, (C 1-2 )alkyl CO 2 (C 1-8 ) alkyl or C 1-8 aldehydroalkyl where the aldehyde function is protected by a suitable protecting group (for example, an acetal such as a dimethyl acetal); n R 4 represents a hydrogen atom, C 1-8 alkyl or C 2-8 alkenyl; n Z represents a group (CH 2 ) n or a branched alkyl chain; n n is 1 to 8; n and each of a, b and c is independently a single or a double bond; n can be prepared relatively easily and in good xxx at room temperature by reacting a compound of general formula II ##STR2## wherein R 2 , R 3 , R 4 , Z, a, b and c are as define din general formula I; with a compound of general formula III n n CHI.sub.2 R.sup.1 (III) n n wherein R 1 is as defined in general formula I; n in the presence of metal ions such as chromium (II) ions. The sever conditions of the Wittig reaction can therefore be avoided. n Compounds of formula I are useful intermediates in the synthesis of mevinic acids, which are potent inhibitors of HMG-CoA reductase and which are useful in the treatment of hypocholesterolaemia an hyperlipidaemia.

专利号:US-6525096-B1
优先权日:1990-11-27
标题:GABA and L-glutamic acid analogs for antiseizure treatment
发明人：SILVERMAN RICHARD B; ANDRUSZKIEWICZ RYSZARD; YUEN PO-WAI
权利人:UNIV NORTHWESTERN; WARNER LAMBERT CO
摘要:A compound of the formulawherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.

专利号:WO-2023088077-A1
优先权日:2021-11-21
标题 :Biocatalysts and methods for the synthesis of pregabalin intermediates

专利号:US-2003191322-A1
优先权日:1997-08-15
标题:Synthesis of clasto-lactacystin beta-lactone and analogs thereof