CAS: 346-06-5; (2-(Trifluoromethyl)Phenyl)Methanol

上下游产品

CAS号21742-00-7 2-(三氟甲基)氯苄 | CAS号312-94-7 2-三氟甲基苯甲酰氯 | CAS号433-97-6 邻三氟甲基苯甲酸 | CAS号50-00-0 甲醛 | CAS号3796-19-8 2-trifluorometh... | CAS号395-47-1 (2-(trifluorome... | CAS号395-44-8 2-(三氟甲基)苄溴 | CAS号447-61-0 邻三氟甲基苯甲醛 | CAS号433-97-6 邻三氟甲基苯甲酸 | CAS号3038-47-9 邻三氟甲基苯乙腈 | CAS号21742-00-7 2-(三氟甲基)氯苄 | CAS号3038-48-0 2-三氟甲基苯乙酸 | CAS号823189-03-3 1-(azidomethyl)...

2-三氟甲基苯甲酰氯置于sodium Tetrahydroborate,Potassium Carbonate体系中,用 二氯甲烷,水 用作溶剂,化学反应生成2-三氟甲基苯甲醇
参考文献:在二氯甲烷水溶液中用硼氢化物将酰氯实际和化学选择性地还原为醇
标题:在二氯甲烷水溶液中用硼氢化物将酰氯实际和化学选择性地还原为醇
摘要:已开发出一种将酰氯还原为其相应醇的简单方法.在低温相转移催化剂的存在下,在二氯甲烷和水 (1:1) 的混合溶剂体系中,使用 Nabh4-K2Co3 将各种羧酸转化为醇,收率极好.这项工作的重要性在于它的简单性,选择性,出色的收率和非常短的反应时间.这种新的还原条件已被证明是在各种官能团存在下对一系列酰氯的出色化学选择性方法.
Doi:10.1080/00397910903340645

专利信息

专利号:US-5932726-A
优先权日:1996-12-16
标 题 :Asymmetric synthesis of benzoxazinones
发明人：PIERCE MICHAEL ERNEST; CHOUDHURY ANUSUYA; PARSONS JR RODNEY LAWRENCE; RADESCA LILIAN ALICIA
权利人:DU PONT PHARM CO
摘要:The present invention provides novel methods for the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one of formula (VI-i) ##STR1## which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor.

专利号:US-7462738-B2
优先权日:2006-05-24
标题:Processes for the preparation of R-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
发明人：HEDVATI LILACH; GILBOA EYAL; AVHAR-MAYDAN SHARON
权利人:TEVA PHARMA
摘要:Provided are processes for the synthesis of R-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid and salts thereof, intermediates in the synthesis of S-pregabalin.

专利号:WO-9845278-A1
优先权日:1997-04-07
标题:Asymmetric synthesis of benzoxazinones via new intermediates

专利号:WO-9827073-A1
优先权日:1996-12-16
标题 :Asymmetric synthesis of benzoxazinones

专利号:WO-9827034-A1
优先权日:1996-12-16
标题:An improved synthesis of cyclopropylacetylene

专利号:NZ-336163-A
优先权日:1996-12-16
标题 :A method of asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-1,3-benzoxazin-2-one derivatives