参考文献:10.1016/j.bmc.2010.03.043 摘要:Al-Nadaf A, Abu Sheikha G, Taha MO. Elaborate ligand-based pharmacophore exploration and QSAR analysis guide the synthesis of novel pyridinium-based potent beta-secretase inhibitory leads. Bioorg Med Chem. 2010 May 01;18(9):3088–115. doi: 10.1016/j.bmc.2010.03.043.