CAS: 3397-35-1; Z-Leu-Osu

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CAS号6066-82-6 N-羟基琥珀酰亚胺 | CAS号2018-66-8 N-苄氧羰基-L-亮氨酸 | CAS号3303-31-9 (S)-2-((S)-2-氨基... | CAS号2873-36-1 环(L-脯氨酰-L-亮氨酰) | CAS号7801-71-0 N-苄氧羰基-L-亮氨酰-L-亮氨酸 | CAS号83510-60-5 Phenylmethyl (S... | CAS号42537-96-2 (2S,3S)-2-((S)-... | CAS号40290-56-0 Z-Leu-Ser-OMe

N-羟基丁二酰亚胺,N-苄氧羰基-L-亮氨酸置于n,N'-二环己基碳二亚胺体系中,用 四氢呋喃 作为反应溶剂,化学反应 1.0H,反应生成 Cbz-L-亮氨酸n-羟基琥珀酰亚胺脂
参考文献:通过蛋白原性侧链有效获得对映体纯的γ4-氨基酸,并研究混合肽螺旋中γ4-Asn和γ4-Ser的结构
标题:通过蛋白原性侧链有效获得对映体纯的γ4-氨基酸,并研究混合肽螺旋中γ4-Asn和γ4-Ser的结构
摘要:由α-和β-氨基酸组成的杂合肽最近已成为一类新型的肽折叠剂.相比较而言,γ的组成γ-和混合γ-肽4-氨基酸比其β-对应物少的研究.然而,最近的研究表明,γ 4-氨基酸有较高的倾向折叠成有序的螺旋结构.作为氨基酸侧链的官能团起到生物上下文中的关键作用,本研究的目的是调查γ的有效合成4-残基与官能蛋白原侧链和在混合的肽序列的结构分析.在这里,各种n-末端和c-末端游离-γ的有效和对映体纯合成4-残基,从苄基酯(coobzl)起始ñ-Cbz保护的(ë)-α,报道β不饱和γ氨基通过在单锅催化氢化多个氢解和双键还原酸.8未受保护的γ的结晶构象,4-氨基酸(γ 4-Val,γ 4-Leu,γ 4-Ile,γ 4-Thr(o吨丁基),γ 4-Tyr,γ 4-Asp(o吨卜),γ 4-Glu(o吨丁基),和γ-Aib)显示,这些氨基酸通过一个螺旋利于笨拙沿着中心ç构象γ  ç β键.来研究γ行为4
DOI:10.1002/chem.201302732

专利信息

专利号:US-4504415-A
优先权日:1983-04-04
标题:Synthesis of thymosin α1 and desacetyl thymosin α1
发明人：FELIX ARTHUR M; GILLESSEN DIETER; STUDER ROLF; MEIENHOFER JOHANNES A; TRZECIAK ARNOLD
权利人:HOFFMANN LA ROCHE
摘要:An improved solution phase synthesis of thymosin alpha 1 and desacetyl thymosin alpha 1 with t-Boc side chain protection and proceeding through novel intermediates is disclosed.

专利号:US-4517119-A
优先权日:1983-04-04
标题:Synthesis of thymosin α1
发明人：FELIX ARTHUR M; GILLESSEN DIETER; LERGIER WILLIAM; MEIENHOFER JOHANNES A; TRZECIAK ARNOLD
权利人:HOFFMANN LA ROCHE
摘要:An improved solution phase synthesis of thymosin α 1 and proceeding through novel intermediates is disclosed.

专利号:US-3953416-A
优先权日:1971-12-20
标 题:Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for manufacturing the same
发明人：FOLKERS KARL; CURRIE BRUCE L; CHANG JAW-KANG; SIEVERTSSON HANS; BOGENTOFT CONNY
权利人:FOLKERS KARL; CURRIE BRUCE L; CHANG JAW KANG; SIEVERTSSON HANS; BOGENTOFT CONNY
摘要:A synthetic decapeptide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucy l-L-arginyl-L-prolyl-glycinamide which has the hormonal activities of the luteinizing hormone releasing hormone (LRH) of the hypothalamus gland of mammals is produced by utilizing as the key starting materials, the amino acids, glutamic acid or pyroglutamic acid, histidine, tryptophan, serine, tyrosine, glycine, leucine, arginine, and proline. Synthesis of the decapeptide is accomplished by coupling, in appropriate combinations of appropriate protected forms of the amino acids, and finally deprotecting to yield the amide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucy l-L-arginyl-L-prolyl-glycinamide.

专利号:US-3725380-A
优先权日:1969-04-05
标 题:Method of synthesizing peptides in the presence of a carbodiimide and a 1-hydroxy-benzotriazole
发明人：KONIG W; GEIGER R
权利人:HOECHST AG
摘要:Improved synthesis of peptides by the carbodiimide method in which an amino-protected amino acid or peptide having a reactive carboxy group is condensed with a carboxy-protected amino acid or peptide having a reactive amino group in the presence of a 1hydroxy-benzotriazole or a substituted 1-hydroxy-benzotriazole of the formula AS WELL AS IN THE PRESENCE OF A CARBODIIMIDE SUCH AS DICYCLOHEXYL CARBODIIMIDE.

专利号:WO-0071569-A1
优先权日:1999-05-26
标题 :Minimal isolation peptide synthesis process using ion-exchange resins as scavenging agents
发明人：TOLLE JOHN C; CALIFANO JEAN-CHRISTOPHE; DHAON MADHUP K; SACHS HOWARD A; BLODGETT JAMES K
权利人:ABBOTT LAB
摘要:A process for the production of a polypeptide having a pre-determined number and sequence of amino acid residues, comprising the steps of first exposing a first substrate amino acid or peptide fragment to a stoichiometric excess of a second reactant amino acid or peptide fragment to form a condensation product; second, contacting the reaction solution from the first step with an insoluble scavenger to sequester the excess of the second reactant amino acid or peptide fragment; third, removing from the solution the sequestered excess second reactant amino acid or peptide fragment; fourth, subjecting the reaction solution to a reaction which removes the protecting group from either the N- or C-terminus of the condensation product of the first step; and fifth, if necessary, repeating the first through fourth steps. The method is capable of large-scale production of peptides in solution, is not subject to the one-terminus-only limitation of the solid-phase method, possesses the 'cleanliness' of the solid-phase method and, like the solid-phase method, is capable of automation. Most importantly, however, the method of the present invention does not require the frequent isolation of intermediates in a lengthy synthetic sequence nor, necessarily, the removal of all contaminating by-products from the reaction mixture prior to subsequent processing steps.

专利号:MX-PA01012082-A
优先权日:1999-05-26
标 题 :SYNTHESIS PROCESS OF MINIMUM INSULATION PEPTIDES, USING ION EXCHANGE RESINS AS CLEANING AGENTS.