CAS: 2390-54-7; 2-(4-(Dimethylamino)Phenyl)-3,6-Dimethylbenzo[d]Thiazol-3-Ium Chloride

相似化合物

92-36-4 10205-62-6 10205-71-7

上下游产品

methanol 2-(4-aminophenyl)-6-methyl-1,3-benzothiazole N,N-dimethyl-4-(6-methylbenzo[d]thiazole-2-yl)aniline methyl iodideN,N-dimethyl-4-(6-methylbenzo[d]thiazole-2-yl)aniline [2-(4-(dimethylamino)phenyl)-3,6-dimethylbenzo[d]thiazol-3-ium] iodide

N,N,N-Trimethyl-4-(6-Methyl-Benzothiazol-2-yl)-Anilinium; Chloride 反应生成硫黄素 T
参考文献:驱虫性季盐.3.苯并噻唑盐.
标题:驱虫性季盐.3.苯并噻唑盐.
摘要:
Doi:10.1021/jm00301A008

专利信息

专利号:US-9868783-B2
优先权日:2013-07-04
标 题:Inhibition of the synthesis of beta-app or the activity of the A-β peptide in the choroid plexus
发明人：DI NARDO ARIEL; MOYA KENNETH LEE; ARNAUD KAREN; PROCHIANTZ ALAIN
权利人:CENTRE NAT RECH SCIENT; COLLEGE FRANCE; INSTITUT NATIONAL DE LA SANTE ET DE LA RECH MEDICALE (INSERM); INST NAT SANTE RECH MED
摘要:The invention relates to the treatment of neurodegenerative diseases, in particular Alzheimer's disease, by inhibition of the synthesis of βAPP or of the activity of the Aβ peptide in the choroid plexus.

专利号:US-9662347-B2
优先权日:2010-05-11
标题 :Method for inhibiting the induction of cell death by inhibiting the synthesis or secretion of age-albumin in cells of the mononuclear phagocyte system
发明人：LEE BONG HEE; BYUN KYUNG HEE
权利人:LEE BONG HEE; BYUN KYUNG HEE; GACHON UNIV OF INDUSTRY-ACADEMIC COOP FOUND
摘要:The present invention relates to a method for inhibiting the induction of cell death by inhibiting the synthesis or secretion of AGE-albumin in cells of the mononuclear phagocyte system, to an AGE-albumin synthesis inhibitor, and to a pharmaceutical composition comprising the AGE-albumin synthesis inhibitor for preventing or treating degenerative disease and autoimmune disease. The AGE-albumin of the present invention is synthesized and secreted in human microglia or human macrophages in an Alzheimer's model, stroke model, Parkinson's disease model and rheumatoid arthritis model. The AGE-albumin synthesis and secretion are caused by oxidative stress. The expression of RAGE increases in first-order human neurons or cartilage cells to which AGE-albumin is administered, whereupon a MAPK signaling pathway is activated and the expression of Bax increases to induce an increase in calcium in mitochondria, thus finally inducing cell death. Therefore, the AGE-albumin synthesis inhibitor of the present invention can be valuably used in the diagnosis or treatment of degenerative diseases or autoimmune diseases such as Alzheimer's disease, strokes, Parkinson's disease, amyotrophic lateral sclerosis, rheumatoid arthritis, diabetic retinopathy, AIDS, aging, pulmonary fibrosis, spinal cord injuries, etc.

专利号:WO-2024199465-A1
优先权日:2023-03-30
标 题:Unnatural amino acid in cellulo synthesis for site-specific protein modification
发明人：CHAN MICHAEL KENNETH; LEE MARIANNE; CHENG JIAHUI
权利人:UNIV HONG KONG CHINESE
摘要:Provided are genetically modified host cells containing engineered enzymes that support the synthesis of unnatural amino acids, such as D-Cys-ε-Lys, and the incorporation of such unnatural amino acids into a newly synthesized protein. These cells are therefore capable of in vivo or in cellulo synthesis of a protein containing one or more unnatural amino acids strategically placed at pre-determined locations for site-specific modification of the protein. Also provided are the corresponding methods for in vivo synthesis of modified proteins as well as the modified proteins produced by the method.

专利号:US-9133176-B2
优先权日:2002-02-15
标题:Isolation, purification and synthesis of procyanidin B2 and uses thereof
发明人：CASTILLO GERARDO; NGUYEN BETH; CHOI PAULA; LARSEN LESLEY; LORIMER STEPHEN; SNOW ALAN
权利人:CASTILLO GERARDO; NGUYEN BETH; CHOI PAULA; LARSEN LESLEY; LORIMER STEPHEN; SNOW ALAN; PROTEOTECH INC
摘要:Methods for the synthesis, isolation, and purification of procyanidin B2 are disclosed. The synthetic methods utilize epicatechin as a starting material and produce procyanidin B2 in high yields. The isolation methods extract procyanidin B2 from a sample of bark powder from plant matter of the genus Uncaria . The isolated and/or synthesized procyanidin B2 is used to treat amyloid disease, such as Alzheimer's disease and Parkinson's disease as well as improve cognitive performance and increase learning and memory in Alzheimer's patients. Pharmaceutical compositions containing the synthesized and/or isolated procyanidin B2 are also disclosed.

专利号:US-2013243770-A1
优先权日:2005-10-14
标 题:Treating diabetes using inhibitors of il-1
发明人：LAU JESPER
权利人:NOVO NORDISK AS
摘要:The present invention describes a method of treating diabetes or metabolic syndrome with a compound that inhibits (a) IL-1, (b) the synthesis of IL-1, or (c) the release of IL-1.

专利号:US-9580480-B2
优先权日:2011-05-31
标题:Cell-directed synthesis of multifunctional nanopatterns and nanomaterials
发明人：LU TIMOTHY KUAN-TA; CHEN ALLEN YUYIN
权利人:LU TIMOTHY KUAN-TA; CHEN ALLEN YUYIN; MASSACHUSETTS INST TECHNOLOGY
摘要:Aspects of the invention relate to the engineering of biological nanostructures and materials.