CAS: 208110-81-0; 6-Fluoropicolinaldehyde

相似化合物

3939-15-9 402-69-7 455-71-0

上下游产品

2-fluoro-6-methylpyridine tert-Butoxybis(dimethylamino)methane 2-fluoro-6-(dibromomethyl)pyridine 6-fluoropyridine-2-carbonyl chloride 6-(methylthio)pyridine-2-carboxaldehyde

2-氟吡啶-6-羧酸置于氯化亚砜,Pd-Baso4,氢气体系中,化学反应生成6-氟-2-吡啶甲醛
参考文献:Synthesis Of Some Fluorine-Containing Pyridinealdoximes Of Potential Use For The Treatment Of Organophosphorus Nerve-Agent Poisoning
标题:Synthesis Of Some Fluorine-Containing Pyridinealdoximes Of Potential Use For The Treatment Of Organophosphorus Nerve-Agent Poisoning
摘要:Fluoroheterocyclic Aldoximes Were Screened As Therapeutic Agents For The Treatment Of Anticholinesterase Poisoning. 2-Fluoropyridine-3-And-6-Aldoxime,And 3-Fluoropyridine-2-And-4-Aldoxime,Were Synthesised. Attempts To Obtain 3,5,6-Trifluoropyridine-2,4-Bis(Aldoxime) And-2-Aldoxime,However,Proved Unsuccessful. Pentafluorobenzaldoxime Was Prepared By Oximation Of Pentafluorobenzaldehyde. Acid Dissociation Constants (Pk(A)) And Second-Order Rate Constants (K(Ox)-) Of The Fluorinated Pyridinealdoximes Towards Satin Were Measured. 2,3,5,6-Tetrafluoropyridine-4-Aldoxime Had The Best Profile: Its K(Ox)-Approached That Of The Therapeutic Oxime P2S (310 Vs. 120 L Mol(-1) Min(-1)),But Its Higher Pk(A) (9.1 Vs. 7.8) Fell Short Of The Target Figure Of 8 Required For Reactivation Of Inhibited Acetylcholinesterase In Vivo. N-Alkylation Of The Fluorinated Pyridine-Aldoximes May Reduce Their Pk(A) Nearer To 8 And Enhance Their Therapeutic Potential. Crown Copyright (C) 2011 Published By Elsevier B.V. All Rights Reserved.
Doi:10.1016/j.Jfluchem.2011.05.028

专利信息

专利号:CN-113603687-A
优先权日:2021-08-02
标 题:A new method for the synthesis of cyano-substituted imidazo[1,5-a]pyridines