专利号:US-12007376-B2 优先权日:2014-02-26 标题 :Method for determining a concentration of a synthesis component in a radiopharmaceutical sample 发明人:LEBEDEV ARTEM Y; ELIZAROV ARKADIJ M 权利人:TRACE ABILITY INC 摘要:A method for determining a concentration of a synthesis component in a radiopharmaceutical sample comprises providing an indicator, a metal or a metal complex, contacting the radiopharmaceutical sample with the indicator, metal or metal complex for a period of time sufficient to obtain an interaction, measuring an optical characteristic of the interacted components, and determining a concentration of the synthesis component in the radiopharmaceutical sample based on the measured optical characteristic.
专利号:US-2024208898-A1 优先权日:2021-03-25 标 题 :Enamine n-oxides: synthesis and application to hypoxia-responsive prodrugs and imaging agents 发明人:KIM JUSTIN; KANG DAHYE; CHEUNG SHELDON T 权利人:DANA FARBER CANCER INST INC 摘要:Disclosed are compounds and pharmaceutically acceptable salts and stereoisomers thereof that are suitable for diagnosis and the treatment of diseases and disorders characterized by, associate with or which exhibit tissue hypoxia, such as, for example, solid tumors. Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds.
专利号:WO-2024263911-A9 优先权日:2023-06-22 标题 :Methods for the synthesis and linearization of peptidomimetic macrocycles 发明人:KIM JUSTIN; FOWLER ELAINE 权利人:DANA FARBER CANCER INST INC 摘要:Disclosed are methodologies for the macrocyclization and linearization of peptides.
专利号:US-10309947-B2 优先权日:2013-02-27 标题:System and method for radiosynthesis, quality control and dose dispensing 发明人:ELIZAROV ARKADIJ; LEBEDEV ARTEM 权利人:TRACE ABILITY INC 摘要:A system and method for performing radiochemical synthesis, analysis and/or dispensing of radiopharmaceuticals using specially designed disposable components: palettes and caddies, the palette being an assembly of containers not connected with each other for direct material transfer; the caddy being a disposable component used to transfer material between containers on the palettes and/or other locations.
专利号:US-2021102929-A1 优先权日:2014-02-26 标题:Method for determining a concentration of a synthesis component in a radiopharmaceutical sample
专利号:JP-2024512568-A 优先权日:2021-03-25 标 题:Enamine N-oxide: synthesis and application of hypoxia-responsive prodrugs and contrast agents
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合成参考文献
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