CAS: 1824-94-8; (2R,3R,4S,5R,6R)-2-(Hydroxymethyl)-6-Methoxytetrahydro-2H-Pyran-3,4,5-Triol

相似化合物

3396-99-4 29411-57-2 3149-68-6

上下游产品

甲基 β-D-吡喃葡萄糖苷 Methyl Beta-D-Glucopyranoside 709-50-2
Methyl Mannoside 22277-65-2
Lactose 63-42-3
甲基 4-O-Beta-D-半乳糖基-Beta-D-吡喃葡萄糖苷 Methyl β-D-Lactopyranoside 7216-69-5
Methyl α-L-Fucopyranosyl-(1->2)-β-D-Galactopyranoside 24656-23-3
β-半乳糖苷酶 β-D-Galactopyranoside 7296-64-2
D-吡喃葡萄糖 D-Galactose 10257-28-0
2(S)-1-O-Docosanoyl-2-O-Docosanoyl-3-O-β-D-Galactopyranosylglycerol 161777-52-2 Methyl 2,3,4,6-Tetra-O-Acetyl-β-D-Galactopyranoside 5019-23-8 Methyl 3-O-Benzyl-β-D-Galactopyranoside 40010-11-5

β-半乳糖苷酶置于盐酸体系中,用 甲醇 用作溶剂,以98.35%的收率获得甲基-β-D-吡喃半乳糖苷
参考文献: Improved Process For Preparation Of 2,3,4,6-Tetra-O-Benzyl-D-Galactose[fr] Procédé Amélioré De Préparation De 2,3,4,6-Tétra-O-Benzyl-D-Galactose
标题: Improved Process For Preparation Of 2,3,4,6-Tetra-O-Benzyl-D-Galactose[fr] Procédé Amélioré De Préparation De 2,3,4,6-Tétra-O-Benzyl-D-Galactose
摘要:本文提供了一种改进的过程,用于制备苯甲基化的d-半乳糖衍生物,特别是2,3,4,6-四-O-苯甲基-D-半乳糖,该过程提高了产量和纯度,成本效益更好,减少了杂质.

专利信息

专利号:US-5374541-A
优先权日:1993-05-04
标 题 :Combined use of β-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one pot synthesis of oligosaccharides
发明人：WONG CHI-HUEY; GAETA FEDERICO C A
权利人:SCRIPPS RESEARCH INST; CYTEL CORP
摘要:A single reaction vessel process for the synthesis of a sialylated galactoside is disclosed. The synthesis utilizes a β-galactosidase to catalyze the reaction of a galactose-containing substrate and an acceptor to form a new galactosyl glycoside that is then sialylated using a cyclic multienzyme synthesis system to form CMP-sialic acid that sialylates the formed galactosyl glycoside in the presence of an α-sialyltransferase. The value of K m /V max for the formed galactosyl glycoside as a substrate for the α-sialyltransferase is less than one-third the K m /V max value for the galactose-containing substrate for that α-sialyltransferase.

专利号:US-4794176-A
优先权日:1981-06-26
标 题 :Synthesis of tumor antigenic determinant
发明人：LEMIEUX RAYMOND U; RATCLIFFE ROBERT M; BAKER DONALD A
权利人:CHEMBIOMED
摘要:Processes are provided for the synthesis of the human T-antigenic determinant 2-acetamido-2-deoxy-3-O-(β-D-galactopyranosyl)-α-D-galactopyranoside containing an α-O-glycosidically linked bridging arm O--(CH 2 ) n COR. The determinant is coupled to carrier molecules to form artifical T-antigens, and to insoluble supports to form T-immunoadsorbents. The artificial T-antigen is shown to elicit a delayed type hypersensitivity reaction as a diagnostic for the presence of cancer in humans.

专利号:US-4767845-A
优先权日:1980-07-10
标题 :Synthesis of tumor antigenic determinant
发明人：LEMIEUX RAYMOND U; RATCLIFFE ROBERT M; BAKER DONALD A
权利人:CHEMBIOMED LTD
摘要:Processes are provided for the synthesis of the human T-antigenic determinant 2-acetamido-2-deoxy-3-O-(β-D-galactopyranosyl)-α-D-galactopyranoside containing an α-O-glycosidically linked bridging arm O--(CH 2 ) n COR. The determinant is coupled to carrier molecules to form artificial T-antigens, and to insoluble supports to form T-immunoadsorbents. The artifical T-antigen is shown to elicit a delayed type hypersensitivity reaction as a diagnostic for the presence of cancer in humans.

专利号:US-7906460-B2
优先权日:2000-12-13
标 题:Active-site engineering of nucleotidylyltransferases and general enzymatic methods for the synthesis of natural and “unnaturalâ€? UDP- and TDP-nucleotide sugars
发明人：THORSON JON; NIKILOV DIMITAR B
权利人:SLOAN KETTERING INST CANCER
摘要:The present invention provides mutant nucleotidylyl-transferases, such as E p , having altered substrate specificity; methods for their production; and methods of producing nucleotide sugars, which utilize these nucleotidylyl-transferases. The present invention also provides methods of synthesizing desired nucleotide sugars using natural and/or modified E p or other nucleotidyltransferases; and nucleotide sugars synthesized by the present methods. The present invention further provides new glycosyl phosphates, and methods for making them.

专利号:US-4866041-A
优先权日:1980-07-10
标 题 :Synthesis of tumor antigenic determinant
发明人：LEMIEUX RAYMOND U; RATCLIFFE ROBERT M; BAKER DONALD A
权利人:CHEMBIOMED LTD
摘要:Processes are provided for the syntheses of the human T-antigenic determinant 2-acetamido-2-deoxy-3-O-(β-D-galactopyranosyl)-α-D-galactopyranoside containing an α-O-glycosidically linked bridging arm O--(CH 2 ) n COR. The determinant is coupled to carrier molecules to form artificial T-antigens, and to insoluble supports to form T-immunoadsorbents. The artifical T-antigen is shown to elicit a delayed type hypersensitivity reaction as a diagnostic for the presence of cancer in humans.

专利号:EP-0725144-A1
优先权日:1995-02-06
标题 :Process for the preparation of glycosides using glycosidases from ciliates
发明人：KIY THOMAS DR; HOERSCH BRIGITTE DR; MARQUARDT RUEDIGER DR
权利人:HOECHST AG
摘要:The invention relates to a process for the production of glycosides by enzymatic glycosylation by means of α- and β-glycosidases from holotrich ciliates and in particular from Hymenostomatida.n n n Glycosidases from holotrich ciliates are very well suited for the enzymatic synthesis of alkyl glycosides, glycopeptides, di- or oligosaccharides. Preferred glycosyldoren are nitrophenylglycosides, glycosyl fluorides or disaccharides, preferred acceptors are short-chain alcohols, polyhydroxy compounds, in particular monosaccharides, or protected hydroxyamino acids or corresponding peptides.