CAS: 16118-36-8; Methyl 2-Amino-4-(Methylthio)Butanoate Hydrochloride

该化合物是氨基酸甲基甲基硫素的衍生物,其特点是存在甲基酯组和盐盐形式.该化合物一般是白色至白晶状粉,由于存在盐酸,可溶于水中,与自由氨基酸相比,盐酸溶性增强.甲基硫酸本身是一种含有硫磺的基本氨基酸,在蛋白合成和各种代谢过程中发挥着关键作用.甲基乙烷形式经常用于生物化学研究和应用,因为它有助于研究甲基硫磷在生物系统中的作用.盐形式提供了稳定性和易处理,适合医药配方.在安全方面,与许多氨基酸及其衍生物一样,人们普遍认为它具有低毒性,但在处理该物质时应当遵循标准的实验室安全议定书.

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2491-18-1 69630-60-0 56762-93-7

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上下游产品

methanol DL-methionine DL-methionine methyl esterN-[N-(4-methoxy-benzyloxycarbonyl)-methionyl]-glycineN-[N-(4-methoxy-benzyloxycarbonyl)-methionyl]-glycine (R)-α-methylbenzylcarbamoyl-DL-methionine methyl ester B°C-Phe-Met-OMe -N'-carbobenzyloxysulfamideN-1-carbomethoxy-3-(methylthio)propyl-N'-carbobenzyloxysulfamide

合成工艺路线路线简述

    📜Dl-Methionine Methyl Ester置于盐酸体系中,用 水 用作溶剂,化学反应生成Dl-蛋氨酸甲酯盐酸盐
    参考文献:四酰基铑铑(II)与蛋氨酸及其衍生物的加成:1 H和13 C核磁共振波谱和手性识别
    标题:四酰基铑铑(II)与蛋氨酸及其衍生物的加成:1 H和13 C核磁共振波谱和手性识别
    摘要:铑(II)二聚体tetraacylates的络合:四乙的rh 2 Aco 4,Tetratrifluoroacetate的rh 2 Tfa 4,和(小号)-Mosher的酸式盐的rh 2 Mtpa 4与两个对映体纯和外消旋甲硫氨酸及其衍生物:甲硫氨酸的盐酸盐,盐酸蛋氨酸甲酯,盐ñ甲酰基甲硫氨酸,ñ-Phthaloyl甲硫氨酸,ñ-Phthaloyl甲硫氨酸和的甲基酯甲基酯ñ,ñ-Dimethylmethionine已经借助于研究1 H和13在可见光范围内的c核磁共振(1 H和13 C NMR)和吸收电子光谱.根据配体和铑盐的溶解度,在d 2 O或cdcl 3溶液中研究了络合过程.使用13 C和15 N Cpmas NMR技术在固相中进行了一些支持性测量.
    Doi:10.1016/j.Tetasy.2010.08.010

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    专利信息


    专利号:US-5316935-A
    优先权日:1992-04-06
    标题 :Subtilisin variants suitable for hydrolysis and synthesis in organic media
    发明人：ARNOLD FRANCES H; CHEN KEQIN
    权利人:CALIFORNIA INST OF TECHN
    摘要:In accordance with the present invention, there are provided novel, modified subtilisin enzyme(s) having improved catalytic activity and/or stability in organic media.

    专利号:US-3948971-A
    优先权日:1972-05-03
    标题 :N-protected-α-amino acid compounds
    发明人：VEBER DANIEL F; BRADY STEPHEN F
    权利人:MERCK & CO INC
    摘要:Novel N-protected-α-amino acid compounds are disclosed in which the amino functionality is protected by a 1-methylcyclobutyloxycarbonyl or 1-methylcyclohexyloxycarbonyl. Processes for the synthesis of amino acids containing these protecting groups and the use of these novel amino acid compounds in the preparation of peptides are also disclosed.

    专利号:JP-2001519769-A
    优先权日:1996-11-22
    标 题 :N- (aryl / heteroaryl) amino acid derivatives, pharmaceutical compositions thereof and methods of inhibiting the release of β-amyloid peptide and / or the synthesis thereof using the compounds

    专利号:CN-102351931-B
    优先权日:2010-09-07
    标题:Pyrimidine nucleoside derivatives, synthesis method and application in preparation of antitumor and antiviral drugs

    专利号:CN-113912524-A
    优先权日:2021-10-25
    标题 :A kind of polypeptide compound containing thioamide and synthesis method thereof

    专利号:CN-113912524-B
    优先权日:2021-10-25
    标题:A kind of sulfur amide-containing polypeptide compound and its synthesis method

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    合成参考文献


    摘要:Liao, L.; Zhang, Y.; Yu, J.-S., Science of Synthesis: Knowledge Updates, (2024) 1, 236.
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