CAS: 159997-94-1; 1,7-Di(Pyridin-3-yl)Heptan-4-Yl (S)-1-(2-Oxo-2-(3,4,5-Trimethoxyphenyl)Acetyl)Piperidine-2-Carboxylate

该化合物是一个小分子,主要发挥多种药物抗药性调控器的作用,其特点是能够抑制某些ATP装有抗药性磁带(ABC)运输器的活动,特别是P-glycoprotein(P-gp),该磁带在各种癌症细胞中往往表现过量.这种过度表情可能导致乳胶化剂的功效降低,使Biricodar成为提高癌症治疗效力的潜在候选体.该物质通常在临床环境中管理,并与其他抗癌药物一起受到调查,以改善治疗结果.其行动机制涉及药物抗药性逆转,允许细胞内细胞内热疗剂浓度增加.Biricodar经过了各种临床试验,以评估其安全性,可耐性和不同类型癌症的功效.与许多调查药物一样,其使用取决于正在进行的研究,以更好地了解其药效,最佳剂量疗法和潜在副作用.

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    专利号:US-12391691-B2
    优先权日:2018-11-16
    标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
    发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
    权利人:AMGEN INC
    摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

    专利号:US-2025206736-A1
    优先权日:2019-11-14
    标题 :Synthesis of kras g12c inhibitor compound
    发明人：CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN
    权利人:AMGEN INC
    摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.

    专利号:US-2025241876-A1
    优先权日:2023-07-19
    标 题:Anti-tumor compounds and methods of use thereof and synthesis thereof
    发明人：QUAY STEVEN CARL
    权利人:ATOSSA THERAPEUTICS INC
    摘要:Described herein are pharmaceutical compounds and compositions and methods of making thereof. Methods of synthesis for the compounds are described herein. The compounds or compositions described herein may exhibit aromatase inhibition activity or estrogen receptor activity. The compounds and compositions described herein may be useful in the treatment of a condition in a subject.

    专利号:US-2023192682-A1
    优先权日:2019-11-14
    标题:Improved synthesis of kras g12c inhibitor compound

    专利号:US-2023192681-A1
    优先权日:2019-11-14
    标 题 :Improved synthesis of kras g12c inhibitor compound

    专利号:WO-2020102730-A1
    优先权日:2018-11-16
    标 题:Improved synthesis of key intermediate of kras g12c inhibitor compound

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    主要参考文献


    1: Aygül A. [The importance of efflux systems in antibiotic resistance and efflux pump inhibitors in the management of resistance]. Mikrobiyol Bul. 2015 Apr;49(2):278-91. Review. Turkish. doi: 10.1016/j.bcp.2013.01.015. Epub 2013 Jan 24.
    3: Chapman JV, Gouazé-Andersson V, Karimi R, Messner MC, Cabot MC. P-glycoprotein antagonists confer synergistic sensitivity to short-chain ceramide in human multidrug-resistant cancer cells. Exp Cell Res. 2011 Jul 15;317(12):1736-45. doi: 10.1016/j.yexcr.2011.03.004. Epub 2011 Mar 21.
    4: Van Bambeke F, Pagès JM, Lee VJ. Inhibitors of bacterial efflux pumps as adjuvants in antibiotic treatments and diagnostic tools for detection of resistance by efflux. Recent Pat Antiinfect Drug Discov. 2006 Jun;1(2):157-75. Review. Review. Review.

    合成参考文献


    参考文献:10.1007/s10147-003-0368-y
    摘要:Yanagisawa T. Systemic chemotherapy as a new conservative treatment for intraocular retinoblastoma. International Journal of Clinical Oncology. 2004 Feb 01;9(1):13–24. doi: 10.1007/s10147-003-0368-y.
    摘要:Fazly Bazzaz BS, Iranshahi M, Naderinasab M, Hajian S, Sabeti Z, Masumi E. Evaluation of the effects of galbanic acid from Ferula szowitsiana and conferol from F. badrakema, as modulators of multi-drug resistance in clinical isolates of Escherichia coli and Staphylococcus aureus. Res Pharm Sci. 2010 Jan;5(1):21–8.
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