CAS: 15474-96-1; (2-Chloroacetyl)Glycylglycine

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556-33-2 7093-67-6 637-84-3

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CAS号556-50-3 双甘肽 | CAS号79-04-9 氯乙酰氯 | CAS号556-33-2 甘氨酰甘氨酰甘氨酸 | CAS号106-57-0 甘氨酸酐 | CAS号13059-60-4 双甘氨肽盐酸盐一水合物 | CAS号18479-98-6 Sar-Gly-Gly-OH | CAS号556-50-3 双甘肽 | CAS号106-57-0 甘氨酸酐 | CAS号556-33-2 甘氨酰甘氨酰甘氨酸 | CAS号7093-67-6 五甘氨酸 | CAS号637-84-3 四聚甘氨酸 | CAS号104186-69-8 2-[[2-[[2-[(2-c... | CAS号16194-06-2 甘氨酰-甘氨酰-甘氨酸乙酯盐酸盐

📜甘氨酸酐置于sodium Hydroxide体系中,化学反应生成氯乙酰基甘氨酰甘氨酸
参考文献:Fischer,E.,Chemische Berichte,1906,Vol. 39,P. 2931
标题:Fischer,E.,Chemische Berichte,1906,Vol. 39,P. 2931

专利信息

专利号:US-4786684-A
优先权日:1986-08-21
标题 :Benzylthioether-linked solid support-bound thiol compounds and method for peptide synthesis
发明人：GLASS JOHN D
权利人:SINAI SCHOOL MEDICINE
摘要:A method for the synthesis of sulfydryl-containing peptides which comprises forming a benzylthioether-linked solid support-bound thiol compound having at least one functional group for generating at least one peptide bond, sequentially coupling at least one protected amino acid or peptide to the compound until a peptide having desired amino acid sequence is obtained, and cleaving the benzylthioether linkage to release the peptide from the support with concomitant regenertion of the sulfydryl group in the peptides. The invention also encompasses compounds having the general formula wherein X is H, NH2, or acyl-NHY, said acyl being an amino acid or a peptide; Y is H, COOH, CONHNH2, the ester COOR1 in which R1 is selected from the group consisting of methyl, ethyl, phenyl, ortho-nitrophenyl and para-nitrophenyl, the amide CONH2, or the amide CONHR2 in which R2 is an amino acid or peptide; and providing that X and Y cannot both be H.

专利号:US-5066716-A
优先权日:1988-12-13
标题:Synthesis of chloroacetyl and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides
发明人：ROBEY FRANK A; FIELDS RAYMOND L; LINDNER WOLFGANG
权利人:US HEALTH
摘要:A method to incorporate bromoacetyl and chloroacetyl moieties on amino groups of synthetic peptides using a standard program with an automated peptide synthesizer has been developed. The bromoacetyl and chloroacetyl-derivatized peptides react well with sulfhydryl-containing proteins and with peptides containing cysteine residues. Autopolymerization or cyclization occurs by reaction of the free sulfhydryl of cysteine in a peptide with the bromoacetyl group (or chloroacetyl group) and reactions can generally be controlled by controlling the concentrations of starting peptide in neutral pH buffers. Analytical methods for evaluating the polymers or cyclized peptides include gel filtration chromatography, reverse phase HPLC, SDS-PAGE and amino acid analysis where the degree of reaction can be evaluated by quantifying the amount of S-carboxymethylcysteine formed after HCl hydrolysis. N-bromoacetyl-derivatized peptides are useful as reagents for potential peptide immunogens, vaccines and therapeutics, and for substances such as peptides linked to polymers, plastics, enamels, and ceramics.

专利号:TW-205552-B
优先权日:1992-09-19
标题:Novel synthesis of radiopharmaceuticals for renal function imaging