CAS: 15097-49-1; 1-(Trimethylsilyl)Pyrrolidine

该化合物是一种有机化合物,其特征是存在一种含有五人饱和含氮的乙基环,即五人组成的饱和氮环.有机合成中常见的保护组三甲基硅基,附于丙醇的氮原子中.这种改变增强了该化合物在有机溶剂中的稳定性和溶性,使其在各种合成应用中有用.三甲基硅基的出现还影响该化合物的再活动,经常促进核分裂替代反应,同时保护氮不受不必要反应.1-(三甲基硅)丙烯基氨通常无色可与有特色的黄色液体染色,在二氯乙烷和醚等常见有机溶剂中可溶性.该化合物用于有机合成,特别是用于制作更复杂的分子,并在各种化学反应中充当试剂,包括涉及形成碳硝基联结的化学反应.在处理该化合物时,安全防范措施可能构成健康风险.

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14468-90-7 22041-19-6 42729-56-6

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ECHA物质C&L通报REACH预注册

上下游产品

pyrrolidine chloro-trimethyl-silane N,O-bis-(trimethylsilyl)-acetamide 1,1,1,3,3,3-hexamethyl-disilazane 2-phenyl-6-pyrrolidin-1-yl-[1,3,5]oxadiazin-4-one 4-pyrrolidin-1-ylpyridine N-(phenylseleno)pyrrolidine bis-(pyrrolidino) methoxyphosphine

合成工艺路线路线简述

    📜四氢吡咯,N,O-双三甲硅基乙酰胺 以 乙腈 用作溶剂,化学反应 1.0H,反应生成1-三甲硅基吡咯烷
    参考文献:由酰基氟和n-甲硅烷基胺合成酰胺的新方法
    标题:由酰基氟和n-甲硅烷基胺合成酰胺的新方法
    摘要:N-甲硅烷基胺与水解稳定的酰基氟在温和条件下容易形成酰胺键.
    Doi:10.1016/s0040-4039(00)95601-6

    海关参考信息

    专利信息


    专利号:EP-0901500-B1
    优先权日:1996-05-03
    标题:In situ preparation of nucleoside phosphoramidites and their use in synthesis of oligonucleotides
    发明人：ZHANG ZHAODA; TANG JIN-YAN
    权利人:AVECIA BIOTECHNOLOGY INC
    摘要:The invention provides novel bifunctional phosphitylating reagents and their application in in situ preparation of 5'-protected nucleoside phosphoramidites and synthesis of oligonucleotides. Bifunctional phosphitylating reagents according to the invention react quickly with nucleosides under weakly acidic conditions. In addition, the bifunctional phosphitylating reagents according to the invention generate chemoselectively the corresponding nucleoside phosphoramidites in situ, without need to purify the nucleoside phosphoramidites before using them in oligonucleotide synthesis. Finally, the bifunctional phosphitylating reagents according to the invention are relatively stable and easy to handle.

    专利号:US-6340749-B1
    优先权日:1995-10-06
    标题:Preparation of nucleoside phosphoramidites and oligonucleotide synthesis
    发明人：ZHANG ZHAODA; TANG JIN-YAN
    权利人:AVECIA BIOTECHNOLOGY INC
    摘要:The invention provides novel bifunctional phosphitylating reagents and their application in in situ preparation of 5'-protected nucleoside phosphoramidites and synthesis of oligonucleotides. Bifunctional phosphitylating reagents according to the invention react quickly with nucleosides under neutral or weakly basic conditions, without an additional activation step. In addition, the bifunctional phosphitylating reagents according to the invention generate chemoselectively the corresponding nucleoside phosphoramidites in situ, without need to purify the nucleoside phosphoramidites before using them in oligonucleotide synthesis. Finally, the bifunctional phosphitylating reagents according to the invention are relatively stable and easy to handle.

    专利号:WO-9742208-A1
    优先权日:1996-05-03
    标题 :In situ preparation of nucleoside phosphoramidites and their use in synthesis of oligonucleotides

    专利号:EP-0901500-A1
    优先权日:1996-05-03
    标 题:$i(IN SITU) PREPARATION OF NUCLEOSIDE PHOSPHORAMIDITES AND THEIR USE IN SYNTHESIS OF OLIGONUCLEOTIDES

    专利号:CA-2226111-C
    优先权日:1996-05-03
    标 题 :In situ preparation of nucleoside phosphoramidites and their use in synthesis of oligonucleotides

    专利号:WO-9742202-A1
    优先权日:1996-05-09
    标 题:In situ preparation of nucleoside phosphoramidites and oligonucleotide synthesis

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    合成参考文献


    摘要:Zhang, Q.-W.; An, K.; He, W., Science of Synthesis Knowledge Updates, (2020) 3, 19.
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