CAS: 13360-66-2; 3,9-Dihydroxy-8-Methoxy-6H-Benzofuro[3,2-C]Chromen-6-One

上下游产品

c]chromen-6-one3,9-bis-benzyloxy-8-methoxy-benzo[4,5]furo[3,2-c]chromen-6-one 3-Benzyloxybenzaldehyde 3-Benzyloxyphenol 7-benzyloxy-2H-1-benzopyran

📜3-苄氧基苯甲醛置于palladium On Activated Charcoal,Palladium Dichloride 盐酸,氢氧化钾,氢气,间氯过氧苯甲酸,2,3-二氯-5,6-二氰基-1,4-苯醌,Lithium Chloride体系中,用 四氢呋喃,二氯甲烷,水,丙酮 用作溶剂,25.0 °C,303.98 Kpa 条件下,反应 84.0H,反应生成3'-甲氧基香豆雌酚
参考文献:Structure-activity Relationship Of Wedelolactone Analogues: Structural Requirements For Inhibition Of Na+,K+-Atpase And Binding To The Central Benzodiazepine Receptor
标题:Structure-activity Relationship Of Wedelolactone Analogues: Structural Requirements For Inhibition Of Na+,K+-Atpase And Binding To The Central Benzodiazepine Receptor
摘要:Coumestans 2A-I,Bearing Different Patterns Of Substitution In A-And D-Rings,Were Synthesized And Evaluated As Inhibitors Of Kidney Na+,K+-Atpase And Ligands For The Central Benzodiazepine (Bzp) Receptor. The Presence Of A Hydroxyl Group In Position 2 Favours The Effect On Na+,K+-Atpase But Decreases The Affinity For The Bzp Receptor,Allowing The Design Of More Selective Molecules Than The Natural Wedelolactone. On The Other Hand,The Presence Of A Catechol In Ring D Is Important For The Effect On Both Molecular Targets.
Doi:10.1016/j.Bmc.2006.07.053