CAS: 129-56-6; Dibenzo[cd,G]Indazol-6(2H)-One

该化合物是一个多环芳烃化合物,其特点是其引信炭疽和丙酮结构.该化合物通常具有深色,通常以暗固态出现,并因其在有机电子,染料和荧光探测器中的潜在用途而闻名,因其强烈的光吸收和排放特性而具有潜在用途.它有一个相对较高的熔点,表明在热条件下具有稳定性.这种聚氨酯的存在有助于其再活性,允许进行各种化学修改.此外,炭疽[1,9-cd] pyrazol-6(2H)-1,可以参与氢联结和欧元堆叠互动,这对于决定其在不同环境中的行为意义重大.其溶剂的溶解度可能因溶剂而不同而不同,通常在有机溶剂中比在水中溶.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号54345-84-5 2-acetyl-2H-dib... | CAS号82-44-0 1-氯蒽醌 | CAS号83132-67-6 Ethyl 9,10-anth... | CAS号82-45-1 1-氨基蒽醌

合成工艺路线路线简述

  • 合成目标产物 1,9-Pyrazoloanthrone 主要起始原料 1-Aminoanthraquinone
  • (文献来源)合成步骤主要原料 1-Aminoanthraquinone
📜2-乙酰基-2H-二苯并[cd,G]吲唑-6-酮置于氨体系中,用 甲醇,水 用作溶剂,化学反应 16.0H,反应生成吡唑蒽酮
参考文献:Methods For Treating Inflammatory Conditions Or Inhibiting Jnk
标题:Methods For Treating Inflammatory Conditions Or Inhibiting Jnk
摘要:本发明通常涉及治疗或预防炎症性疾病或紊乱的方法,包括向需要治疗的患者施用以下结构的吡唑酮衍生物的有效量:1或其药学上可接受的盐,其中r1和r2如此处所定义.

海关参考信息

专利信息


专利号:US-5618944-A
优先权日:1993-05-05
标题:Method for the synthesis of anthrapyrazolones
发明人：ZHANG LIN-HUA; AUERBACH JOSEPH
权利人:DU PONT MERCK PHARMA
摘要:This invention relates to compounds, including 5-chloro-2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]-7-[2,4,6-trimethylphenyl)methoxy]anthra[1,9-cd]pyrazol-6(2H)-one and analogs thereof, which are useful as intermediates for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone. This invention also relates to methods for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone.

专利号:US-9422244-B2
优先权日:2010-01-29
标 题 :Synthesis of substituted pyrazoline carboxamidine derivatives
发明人：VAN LOEVEZIJN ARNOLD; LANGE JOSEPHUS H M; BARF GERRIT A; DEN HARTOG ARNOLD P
权利人:VAN LOEVEZIJN ARNOLD; LANGE JOSEPHUS H M; BARF GERRIT A; DEN HARTOG ARNOLD P; ABBVIE BAHAMAS LTD
摘要:This invention relates to organic chemistry, in particular to processes for the preparation of pyrazoline carboxamidine derivatives of formula (I), known as potent 5-HT6 antagonists. The invention also relates to novel intermediates of these compounds. wherein the symbols have the meanings given in the description.

专利号:WO-2023241717-A1
优先权日:2022-06-16
标题:Substance for promoting regeneration and repair of organs of mammals and use thereof
发明人：LI WEI; ZHOU QI; He zheng-quan; LU ZONGBAO; WANG SHUAI; WANG XIN; YUAN XUEWEI; WANG LIU
权利人:INST ZOOLOGY CAS; BEIJING INST FOR STEM CELL AND REGENERATIVE MEDICINE
摘要:Provided is use of a substance capable of up-regulating ISG gene expression in preparing a drug or reagent for promoting the regeneration and repair capacity of tissues or complex structures or organs of mammals. The substance for up-regulating ISG gene expression is selected from one or two or more of an MAPK inhibitor, a retinoic acid receptor-related orphan receptor inhibitor, a protein synthesis inhibitor, and an interferon (IFNγ, β, λ) or alarmin (S100A8/A9) protein. The regeneration and repair refer to promoting the regeneration of tissues or complex structures or organs after tissue or organ resection or damage.

专利号:WO-2011092226-A1
优先权日:2010-01-29
标 题:Synthesis of substituted pyrazoline carboxamidine derivatives

专利号:US-2013060041-A1
优先权日:2010-01-29
标题:Synthesis of substituted pyrazoline carboxamidine derivatives

专利号:EP-0700390-A1
优先权日:1993-05-05
标 题 :Intermediates and methods for the synthesis of anthrapyrazolone anticancer agents

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主要参考文献


1: Konno T, Ninomiya T, Kohno T, Kikuchi S, Sawada N, Kojima T. c-Jun N-terminal kinase inhibitor SP600125 enhances barrier function and elongation of human pancreatic cancer cell line HPAC in a Ca-switch model. Histochem Cell Biol. 2014 Dec 16. [Epub ahead of print] doi: 10.1371/journal.pone.0114389. eCollection 2014.
3: Kong Q, Hua H, Cui A, Shao T, Song P, Jiang Y. SP600125 induces Src and type I IGF receptor phosphorylation independent of JNK. Int J Mol Sci. 2014 Sep 15;15(9):16246-56. doi: 10.3390/ijms150916246.
4: Cao S, Wang T, Yan B, Lu Y, Guo W, Zhang S. Protective effects of SP600125 in brain death-induced liver injury. Clin Res Hepatol Gastroenterol. 2014 Oct;38(5):577-82. doi: 10.1016/j.clinre.2014.05.004. Epub 2014 Jun 23. Epub 2014 Apr 14.

合成参考文献


参考文献:10.1097/ccm.0b013e3181d44e06
摘要:Chen LW, Tseng HT, Chen PH, Hsu CM. Peritonitis-induced peroxynitrite and lung damage depends on c-Jun NH2-terminal kinase signaling of hematopoietic cells. Crit Care Med. 2010 Apr;38(4):1168–78. doi: 10.1097/ccm.0b013e3181d44e06.
参考文献:10.1186/1476-4598-9-38
摘要:Lynch JT, Rajendran R, Xenaki G, Berrou I, Demonacos C, Krstic-Demonacos M. The role of glucocorticoid receptor phosphorylation in Mcl-1 and NOXA gene expression. Molecular Cancer. 2010 Feb 15;9(1):38. doi: 10.1186/1476-4598-9-38.
参考文献:10.1002/jat.1708
摘要:Valesio EG, Zhang H, Zhang C. Exposure to the JNK inhibitor SP600125 (anthrapyrazolone) during early zebrafish development results in morphological defects. J Appl Toxicol. 2013 Jan;33(1):32–40. doi: 10.1002/jat.1708.
参考文献:10.1179/016164110x12807570509853
摘要:Armstead WM, Willis Kiessling J, Riley J, Cines DB, Higazi AA. tPA contributes to impaired NMDA cerebrovasodilation after traumatic brain injury through activation of JNK MAPK. Neurological Research. 2011 Sep;33(7):726–33. doi: 10.1179/016164110x12807570509853.
参考文献:10.1179/146701010x12671177544104
摘要:Eshraghi AA, Hoosien G, Ramsay S, Dinh CT, Bas E, Balkany TJ, Van De Water TR. Inhibition of the JNK signal cascade conserves hearing against electrode insertion trauma-induced loss. Cochlear Implants Int. 2010 Jun;11 Suppl 1():104–9. doi: 10.1179/146701010x12671177544104.
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