维萘妥拉 ABT-199 CAS 1257044-40-8 衍生项目研发精选

维萘妥拉 ABT-199 CAS 1257044-40-8

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维萘妥拉 ABT-199 CAS 1257044-40-8 系列衍生物及原料研发项目

化合物名称	CAS号
1-环己烯-1-甲醛,2-(4-氯苯基)-4,4-二甲基 1-Cyclohexene-1-carboxaldehyde, 2-(4-chlorophenyl)-4,4-dimethyl	228837-05-5
苯磺酰胺,3-硝基-4-[[(四氢-2H-吡喃-4-基)甲基]氨基] Benzenesulfonamide, 3-nitro-4-[[(tetrahydro 2H-yran-4-yl)methyl]amino]	1228779-96-1
苯甲酸,4-(1-哌嗪基)-2-(1H-吡咯[2,3-b]吡啶-5-氧基)-乙基酯 Benzoic acid, 4-(1-piperazinyl)-2-(1 H-pyrrolo[2,3-b] pyridin-5-yloxy) - ethyl ester	2180923-73-1
苯甲酸, 4-(1-哌嗪基)-2-(1H-吡咯[2,3-b]吡啶-5-氧基)-甲基酯 Benzoic acid, 4-(1-piperazinyl)-2-(1 H -pyrrolo[2,3-b] pyridin-5-yloxy)- methyl ester	1257044-57-7
3-硝基-4-[[(四氢-2H-吡喃-4-基)甲基]氨基]苯磺酰胺 3-Nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]benzenesulfonamide 合成步骤: 将4-氟-3-硝基苯磺酰胺, 4-氨甲基四氢吡喃, 和三乙胺溶于10mL四氢呋喃中. 室温下搅拌反应5小时后,减压蒸馏除去溶剂.向残余物中加入20mL甲醇,经干燥处理后得到3-硝基-4-(((四氢-2H-吡喃-4-基)甲基)氨基)苯磺酰胺产率为97%.	1228779-96-1
2-((1H-吡咯[2,3-B]吡啶-5-基)氧基)-4-((4'-氯-5,5-二甲基-3,4,5,6-四氢-[1,1'-二苯基]-2-基)甲基)哌嗪-1-基)苯甲酸 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid	1235865-77-6
2-(4-氯苯基)-4,4-二甲基环己-1-烯-1-羧酸甲酯 Methyl 2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-ene-1-carboxylate	1228780-49-1
4,4-二甲基-2-氧代环己烷甲酸甲酯 Methyl 4,4-dimethyl-2-oxocyclohexancarboxylate	32767-46-7
2-((1H-吡咯[2,3-B]吡啶-5-基)氧基)-4-(4-((4'-氯-5,5-二甲基-3,4,5,6-四氢-[1,1'-二苯基]-2-基)甲基)哌嗪-1-基)苯甲酸甲酯 Methyl 2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]-4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl]methyl]piperazin-1-yl]benzoate	1235865-76-5
(4'-氯-5,5-二甲基-3,4,5,6-四氢-[1,1'-联苯]-2-基)甲醇 [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methanol	1228780-51-5
4-[[2-(4-氯苯基)-4,4-二甲基环己-1-烯基]甲基]哌嗪-1-羧酸叔丁酯 tert-butyl 4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazine-1-carboxylate	1228780-71-9
1-三异丙基硅基-5-溴-7-氮杂吲哚 5-Bromo-1-triisopropylsilanyl-7-azaindole	858116-66-2
5-溴-7-氮杂吲哚 5-Bromo-7-azaindole	183208-35-7
1-(三异丙基硅烷基)-1H-吡咯并[2,3-B]吡啶-5-醇 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol	685514-01-6
4,4-二甲基-2-[(三氟甲基磺酰基)氧基]环己-1-烯-1-羧酸甲酯 4,4-dimethyl-2-[[(trifluoromethyl)sulfonyl]oxy]-1-cyclohexene-1-carboxylic acid methyl ester	1228780-46-8
4-氟-2-{1H-吡咯并[2,3-B]吡啶-5-基氧基}苯甲酸甲酯 Methyl 2-((1H-pyrrolo[2,3-b]pyrin-5-yl)oxy)-4-fluorobenzoate	1235865-75-4
4-((2-(4-氯苯基)-4,4-二甲基-1-环己烯)甲基)哌嗪 1-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazine	1228780-72-0

📚 参考文献

[1] Patent: CN108658983, 2018, A. Location in patent: Paragraph 0116;0117;0118
[2] Patent: WO2017/156398, 2017, A1. Location in patent: Paragraph 0322
[3] Patent: WO2010/65865, 2010, A2. Location in patent: Page/Page column 226-227
[4] Patent: US2010/160322, 2010, A1. Location in patent: Page/Page column 86
[5] Patent: US2010/305122, 2010, A1. Location in patent: Page/Page column 118
[6] Patent: WO2005/103050, 2005, A2. Location in patent: Page/Page column 180
[7] Patent: WO2006/128692, 2006, A2. Location in patent: Page/Page column 158
[8] Patent: US2007/49615, 2007, A1. Location in patent: Page/Page column 62-63
[9] Patent: US2007/49615, 2007, A1. Location in patent: Page/Page column 68
[10] Patent: CN107089981, 2017, A. Location in patent: Paragraph 0033;0034;0035;0036
[11] Patent: CN108658983, 2018, A. Location in patent: Paragraph 0110;0111;0112
[12] Patent: CN106565706, 2017, A. Location in patent: Paragraph 0188;0189;0190
[13] Patent: WO2017/212431, 2017, A1. Location in patent: Page/Page column 57;58
[14] Patent: WO2018/29711, 2018, A2. Location in patent: Page/Page column 32;33
[15] Patent: CN108658983, 2018, A. Location in patent: Paragraph 0153;0156;0163;0164
[16] Patent: US2010/184766, 2010, A1. Location in patent: Page/Page column 51
[17] Patent: US2010/305122, 2010, A1. Location in patent: Page/Page column 119
[18] Patent: WO2011/150016, 2011, A1. Location in patent: Page/Page column 79
[19] Patent: WO2012/71336, 2012, A1. Location in patent: Page/Page column 10

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