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临床前CDMO研发化合物筛选
L-arginine
中文名称:L-精氨酸
CAS号:74-79-3
分子式: C6H14N4O2 分子量: 174.20
产品形式: free base
研发状态: Not yet recruiting
研发用途: Thiazide Associated Hyponatremia
研究机构: University Hospital Basel Switzerland
研发日期: May-24
研发阶段: Not Applicable
Arginine is an important amino acid used in the biosynthesis of proteins. L-arginine plays an important role in immune regulation by affecting the immune response and inflammation. It is also implicated in cell division, wound healing and the release of hormones.
Luminespib (NVP-AUY922)
中文名称:5-[2,4-二羟基-5-(1-甲基乙基)苯基]-n-乙基-4-[4-(4-吗啉甲基)苯基]-3-异噁唑羧酰胺
CAS号:747412-49-3
分子式: C26H31N3O5 分子量: 465.54
产品形式: free base
研发状态: Completed
研发用途: Anaplastic Lymphoma Kinase (ALK); Non-small Cell Lung Cancer
研究机构: Novartis Pharmaceuticals; Novartis
研发日期: Jun-13
研发阶段: Phase 1
Luminespib (AUY-922, NVP-AUY922, VER-52296) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Luminespib (AUY-922, NVP-AUY922) effectively downregulates and destabilizes the IGF-1Rβ protein and results in growth inhibition, autophagy and apoptosis. Phase 2.
Hydroxychloroquine Sulfate (NSC 4375)
中文名称:硫酸羟基氯喹
CAS号:747-36-4
分子式: C18H28ClN3O5S 分子量: 433.95
产品形式: Sulfate
研发状态: Not yet recruiting
研发用途: Resectable Localized Prostate Cancer
研究机构: Lionel.D.Lewis MD; Dartmouth Cancer Center; Dartmouth-Hitchcock Medical Center
研发日期: Jun-24
研发阶段: Early Phase 1
Hydroxychloroquine Sulfate (NSC 4375, HCQ) is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR) 7/9.
VX-702
中文名称:6-[(氨基羰基)(2,6-二氟苯基)氨基]-2-(2,4-二氟苯基)-3-吡啶甲酰胺
CAS号:745833-23-2
分子式: C19H12F4N4O2 分子量: 404.30
产品形式: free base
研发状态: Completed
研发用途: Rheumatoid Arthritis
研究机构: Vertex Pharmaceuticals Incorporated
研发日期: Nov-06
研发阶段: Phase 2
VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β.
Alprostadil
中文名称: 列腺素 E1
CAS号:745-65-3
分子式: C20H34O5 分子量: 354.48
产品形式: free base
研发状态: Not yet recruiting
研发用途: Heart Failure
研究机构: Biopeutics Co. Ltd
研发日期: Oct-23
研发阶段: Phase 3
Alprostadil (Prostaglandin-E1, PGE1, Edex, Muse, Liprostin) is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. It is a Prostaglandin Analog and Prostaglandin E1 Agonist.
Potassium Chloride
中文名称:氯化钾
CAS号:7447-40-7
分子式: ClK 分子量: 74.55
产品形式: Potassium
研发状态: Not yet recruiting
研发用途: Arthritis of Carpometacarpal Joint of Left Thumb; Arthritis of Carpometacarpal Joint of Right Thumb
研究机构: Brent DeGeorge; University of Virginia
研发日期: June 1 2024
研发阶段: Phase 1
Potassium chloride is an inorganic salt commonly used in fertilizer industry. It is also extensively used as a potassium supplement.
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