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临床前CDMO研发化合物筛选
Fostamatinib (R788)
中文名称:福他替尼
CAS号:901119-35-5
分子式: C23H26FN6O9P 分子量: 580.46
产品形式: free base
研发状态: Not yet recruiting
研发用途: Sickle Cell Disease; Hb-SS Disease; Hemoglobin S; Disease Sickle Cell Anemia; Sickle Cell Disorders; Hemoglobin Beta Thalassemia Disease
研究机构: National Heart Lung and Blood Institute (NHLBI); National Institutes of Health Clinical Center (CC)
研发日期: May 15 2024
研发阶段: Phase 1
Fostamatinib (R788), a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 3.
Rebamipide
中文名称:瑞巴派特
CAS号:90098-04-7
分子式: C19H15ClN2O4 分子量: 370.79
产品形式: free base
研发状态: Completed
研发用途: Healthy Volunteers
研究机构: Korea Otsuka Pharmaceutical Co. Ltd.
研发日期: April 22 2019
研发阶段: Phase 1
Rebamipide (OPC-12759,Proamipide) is a cholecystokinin type 1 (CCK1) receptor inhibitor for inhibiting [125I]BH-CCK-8S with IC50 of 37.7 μM.
Chondroitin sulfate
中文名称: 硫酸软骨素
CAS号:9007-28-7
分子式: (C14H21NO14S)n 分子量: 489.45
产品形式: sulfate
研发状态: Active not recruiting
研发用途: Low Back Pain; Obesity
研究机构: Poznan University of Physical Education
研发日期: September 1 2020
研发阶段: Not Applicable
Chondroitin sulfate (CS) is a major component of the extracellular matrix (ECM) of many connective tissues, including cartilage, bone, skin, ligaments and tendons. It reduces the IL-1β-induced nuclear factor-kB (NF-κB) translocation in chondrocytes in vitro.
Inulin
中文名称: 菊粉
CAS号:9005-80-5
分子式: C6nH10n+2O5n+1 分子量: N/A
产品形式: Free Base
研发状态: Active not recruiting
研发用途: Healthy
研究机构: Indiana University; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
研发日期: August 1 2021
研发阶段: Not Applicable
Inulin(Inulin and sodium chloride), a starch found in the tubers and roots of many plants. Since it is hydrolyzable to fructose, it is classified as a fructosan.
Hyaluronic acid
中文名称:透明质酸
CAS号:9004-61-9
分子式: N/A 分子量: N/A
产品形式: Free Base
研发状态: Not yet recruiting
研发用途: Interstitial Lung Disease; Idiopathic Pulmonary Fibrosis; Lung Diseases Interstitial
研究机构: National Institute of Environmental Health Sciences (NIEHS); National Institutes of Health Clinical Center (CC)
研发日期: May 15 2024
研发阶段: Phase 2
Hyaluronic acid (HA, Hyaluronan, Hyaluronate) is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is widely used in skin care.
Tocofersolan
中文名称:托可索仑
CAS号:9002-96-4
分子式: (C2H4O)nC33H54O5 分子量: 574.83
产品形式: free base
研发状态: Completed
研发用途: Cirrhosis
研究机构: University Hospital Geneva
研发日期: Nov-11
研发阶段: Phase 2
Tocofersolan (Tocophersolan) is a synthetic water-soluble version of vitamin E that is used in treatment of vitamin E deficiency.
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