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临床前CDMO研发化合物筛选
LY3295668
CAS号:1919888-06-4
分子式: C24H26ClF2N5O2 分子量: 489.95
产品形式: Free base
研发状态: Completed
研发用途: Small Cell Lung Cancer
研究机构: Eli Lilly and Company
研发日期: July 16 2019
研发阶段: Phase 1
LY3295668 (AK-01) is a potent, orally active and specific inhibitor of Aurora A kinase with Ki of 0.8 nM and 1038 nM for AURKA and AURKB, respectively.
Lenalidomide (CC-5013)
中文名称:来那度胺
CAS号:191732-72-6
分子式: C13H13N3O3 分子量: 259.26
产品形式: free base
研发状态: Not yet recruiting
研发用途: Cognitive Impairment Mild; Cognitive Dysfunction; Amyloid Plaque; Neurodegenerative Disease Hereditary; Inflammation Brain
研究机构: St. Joseph''s Hospital and Medical Center Phoenix; Texas Tech University
研发日期: January 2 2024
研发阶段: Phase 2
Lenalidomide (CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM in PBMCs. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide promotes cleaved caspase-3 expression and inhibit VEGF expression and induces apoptosis.
Pomalidomide (CC-4047)
中文名称:泊马度胺
CAS号:19171-19-8
分子式: C13H11N3O4 分子量: 273.24
产品形式: free base
研发状态: Recruiting
研发用途: Viral Associated Malignancies; Kaposi Sarcoma; EBV/KSHV-associated Lymphomas
研究机构: National Cancer Institute (NCI); National Institutes of Health Clinical Center (CC)
研发日期: December 10 2021
研发阶段: Phase 1
Pomalidomide (CC-4047) inhibits LPS-induced TNF-α release with IC50 of 13 nM in PBMCs. Pomalidomide can be utilized in PROTAC as a ligand for targeting E3 ligase and inhibiting the E3 ligase protein cereblon (CRBN). Pomalidomide promotes apoptosis and cell cycle arrest.
1-Deoxynojirimycin
中文名称:1-脱氧野尻霉素
CAS号:19130-96-2
分子式: C6H13NO4 分子量: 163.17
产品形式: free base
研发状态: Completed
研发用途: Pompe Disease
研究机构: Amicus Therapeutics
研发日期: October 31 2011
研发阶段: Phase 2
1-Deoxynojirimycin (duvoglustat, moranolin) is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus.
Branebrutinib (BMS-986195)
中文名称:化合物BMS-986195
CAS号:1912445-55-6
分子式: C20H23FN4O2 分子量: 370.42
产品形式: free base
研发状态: Completed
研发用途: Healthy Participants
研究机构: Bristol-Myers Squibb
研发日期: August 2 2020
研发阶段: Phase 1
Branebrutinib (BMS-986195) is a potent inhibitor of BTK with IC50 values of 0.1 nM, 0.9 nM, 1.5 nM, 5 nM for BTK, TEC, BMX, TXK, respectively.
Pramipexole 2HCl Monohydrate
中文名称:盐酸普拉克索一水合物
CAS号:191217-81-9
分子式: C10H17N3S.2HCl.H2O 分子量: 302.26
产品形式: Dihydrochloride monohydrate
研发状态: Not yet recruiting
研发用途: Anxiety Disorders; Anxiety; Depression; Social Disconnection
研究机构: University of California San Diego; National Institute of Mental Health (NIMH); New York State Psychiatric Institute
研发日期: Feb-24
研发阶段: Phase 2
Pramipexole 2HCl Monohydrate is a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease.
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