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临床前CDMO研发化合物筛选
Tenofovir Disoproxil
中文名称:替诺福韦酯
CAS号:201341-05-1
分子式: C19H30N5O10P 分子量: 519.44
产品形式: Free Base
研发状态: Recruiting
研发用途: Chronic Hepatitis b Patients
研究机构: Sohag University
研发日期: April 15 2023
研发阶段: --
Tenofovir Disoproxil (Bis(POC)-PMPA, GS 4331) is a prodrug of tenofovir, which is metabolised intracellularly to its active anabolite tenofovir diphosphate, a competitive inhibitor of HIV-1 reverse transcriptase and terminates the growing DNA chain.
Triapine
中文名称:(E)-2-((3-氨基吡啶-2-基)亚甲基水杨酰硫酰胺
CAS号:200933-27-3
分子式: C7H9N5S 分子量: 195.24
产品形式: free base
研发状态: Completed
研发用途: Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Primary Central Nervous System Hodgkin Lymphoma; Primary Central Nervous System Non-Hodgkin Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Adult T-cell Leukemia/Lymphoma; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Mycosis Fungoides/Sezary Syndrome; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Stage IV Small Lymphocytic Lymphoma; Unspecified Adult Solid Tumor Protocol Specific; Waldenström Macroglobulinemia
研究机构: National Cancer Institute (NCI)
研发日期: Jun-06
研发阶段: Phase 1
Triapine (3-AP) is a potent ribonucleotide reductase (RNR) inhibitor with broad spectrum antitumor activity by inhibiting DNA synthesis. Phase 2.
Cilengitide trifluoroacetate
中文名称:西仑吉肽TFA
CAS号:199807-35-7
分子式: C29H41F3N8O9 分子量: 702.68
产品形式: Trifluoroacetat
研发状态: Terminated
研发用途: Gliomas
研究机构: Martin-Luther-Universität Halle-Wittenberg; Merck KGaA Darmstadt Germany
研发日期: Jan-12
研发阶段: Phase 2
Cilengitide (EMD 121974, NSC 707544) is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.
O6-Benzylguanine
中文名称:O-6-苄基鸟嘌呤
CAS号:19916-73-5
分子式: C12H11N5O 分子量: 241.25
产品形式: free base
研发状态: Completed
研发用途: Brain and Central Nervous System Tumors
研究机构: National Cancer Institute (NCI)
研发日期: Feb-06
研发阶段: Phase 2
O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
PRT543
中文名称:7H-吡咯啧啶-4-胺,7-[(5R)-5-C-(4-氯苯基)-β-D-核呋喃糖]-
CAS号:1989620-03-2
分子式: C17H17ClN4O4 分子量: 376.79
产品形式: free base
研发状态: Completed
研发用途: Relapsed/Refractory Advanced Solid Tumors; Relapsed/Refractory Diffuse Large B-cell Lymphoma; Relapsed/Refractory Myelodysplasia; Relapsed/Refractory Myelofibrosis; Adenoid Cystic Carcinoma; Relapsed/Refractory Mantle Cell Lymphoma; Relapsed/Refractory Acute Myeloid Leukemia; Refractory Chronic Myelomonocytic Leukemia
研究机构: Prelude Therapeutics
研发日期: February 11 2019
研发阶段: Phase 1
PRT543 is a potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) with broad antitumor activity in vitro and in vivo. It also inhibits the methyltransferase activity of the PRMT5/MEP50 complex with an IC50 of 10.8 nM.
Atazanavir
中文名称: 阿扎那韦
CAS号:198904-31-3
分子式: C38H52N6O7 分子量: 704.86
产品形式: free base
研发状态: Active not recruiting
研发用途: HIV/AIDS; Tuberculosis
研究机构: University of Liverpool; European and Developing Countries Clinical Trials Partnership (Funder); Joint Clinical Research Centre Kampala Uganda; University of Cape Town Cape Town South Africa; Infectious Diseases Institute Makerere University College of Health Sciences Kampala Uganda; University of Turin Turin Italy
研发日期: October 30 2020
研发阶段: Phase 2 : Phase 3
Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.
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