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临床前CDMO研发化合物筛选
Spironolactone
中文名称: 螺内酯
CAS号:52-01-7
分子式: C24H32O4S 分子量: 416.57
产品形式: free base
研发状态: Not yet recruiting
研发用途: Edema Due to Heart Failure or Cirrhosis
研究机构: CMP Development LLC
研发日期: Jun-24
研发阶段: Phase 4
Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM.
Norethindrone acetate
中文名称:醋酸炔诺酮
CAS号:51-98-9
分子式: C22H28O3 分子量: 340.46
产品形式: Free Base
研发状态: Not yet recruiting
研发用途: Pregnancy Related; Pregnancy Complications; Pregnancy High Risk
研究机构: Sumitomo Pharma Switzerland GmbH
研发日期: Jan-25
研发阶段: --
Norethindrone acetate (19-Norethindrone acetate, NA) is a common synthetic hormone used in oral contraceptives. Norethindrone acetate is a well-tolerated, effective option to manage pain and bleeding for all stages of endometriosis.
Tasisulam
中文名称: 他斯索兰
CAS号:519055-62-0
分子式: C11H6BrCl2NO3S2 分子量: 415.11
产品形式: free base
研发状态: Terminated
研发用途: Advanced Cancer
研究机构: Eli Lilly and Company
研发日期: Sep-10
研发阶段: Phase 1
Tasisulam (LY573636) is an antitumor agent and an apoptosis inducer via the intrinsic pathway. Phase 3.
Angiotensin (1-7)
中文名称:血管紧张素 (1-7)
CAS号:51833-78-4
分子式: C41H62N12O11 分子量: 899.00
产品形式: Free Base
研发状态: Not yet recruiting
研发用途: Traumatic Brain Injury
研究机构: University of Arizona; United States Department of Defense
研发日期: Mar-24
研发阶段: Phase 1 : Phase 2
Angiotensin (1-7) (Ang-(1-7), Angiotensin fragment 1-7) is a bioactive component of the renin-angiotensin system that is formed endogenously from either Ang I or Ang II. Angiotensin (1-7) is a canine ACE inhibitor with an IC50 of 0.65 μM and inhibits the activity mediated by myostatin through Mas receptor.
Raltegravir (MK-0518)
中文名称: 雷特格韦
CAS号:518048-05-0
分子式: C20H21FN6O5 分子量: 444.42
产品形式: free base
研发状态: Recruiting
研发用途: HIV Infections
研究机构: Centre de Recherches et d''Etude sur la Pathologie Tropicale et le Sida
研发日期: September 15 2020
研发阶段: Phase 2
Raltegravir (MK-0518) is a potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM in cell-free assays, respectively. It shows greater than 1000-fold selectivity for HIV-1 IN over several related Mg2+-dependent enzyme such as HCV polymerase, HIV reverse transcriptase, HIV RNaseH and human α-, β-, γ-polymerases.
Nimesulide
中文名称:尼美舒利
CAS号:51803-78-2
分子式: C13H12N2O5S 分子量: 308.31
产品形式: free base
研发状态: Completed
研发用途: Pain
研究机构: GlaxoSmithKline
研发日期: July 18 2010
研发阶段: Phase 1
Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM.
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