LY-307853

Chemical Name: (3S,6S,9S,11R,15S,18S,20R,21R,24S,25R,26S)-6-[1(S),2(S)-Dihydroxy-2-[4-(phosphonooxy)phenyl]ethyl]-11,20,21,25-tetrahydroxy-3,15-bis[1(R)-hydroxyethyl]-26-methyl-18-(4''-pentyloxy-p-terphenyl-4-carboxamido)-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0(9,13)]he
项目整合开发状态: Preclinical
项目研究机构: Lilly (Originator)
合成路线:The synthesis of LY-307853 (the phosphate prodrug of LY-303366) has been performed:The phosphorylation of LY-303366 (I) with tetrabenzyl pyrophosphate (II) by means of LiOH in DMF gives dibenzyl phosphate (III),which is finally debenzylated by hydrogenation with H2 over Pd/C in the presence of sodium acetate.