新产品编号:1827719
Chemical Name: 2-(4-Amino-2-chlorophenyl)-1H-isoindole-1,3(2H)-dione
项目整合开发状态: Preclinical
项目研究机构: INSERM (Originator), National Institutes of Health (Originator)
合成路线:The condensation between 2-chloro-4-nitroaniline (II) and phthalic anhydride (I) in refluxing acetic acid produced phthalimide (III).The nitro group was then reduced to the desired aniline by transfer hydrogenation employing cyclohexene in the presence of Pd/C.
📌 参考资料/链接：
参考文献标题:Synthesis and anticonvulsant and neurotoxic properties of substituted N-phenyl derivatives of the phthalimide pharmacophore
文献作者:Vamecq,J.; Bac,P.; Herrenknecht,C.; Maurois,P.; Delcourt,P.; Stables,J.P.
参考来源:J Med Chem 2000,43(7),1311