Indanocine, NSC-698666

Chemical Name: 7-Amino-2-[(E)-(4-hydroxy-3,5-dimethylbenzylidene]-5,6-dimethoxyindan-1-one
项目整合开发状态: Biological Testing
项目研究机构: National Cancer Institute (Originator), University of California, San Diego (Originator)
合成路线:5,6-Dimethoxy-1-indanone (I) was selectively nitrated at position 7 by means of NaNO2 in trifluoroacetic acid.Acid-catalyzed aldol condensation of the resulting nitroindanone (II) with 3,5-dimethyl-4-hydroxybenzaldehyde (III) afforded the E-unsaturated ketone (IV).Finally,reduction of the nitro group of (IV) with either sodium dithionite or zinc dust and AcOH yielded the corresponding amino derivative.